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There is preliminary evidence that a dynamic T2 Preparations Puls sequence by cardiac magnet resonance imaging can differentiate between oxygenated and deoxygenated blood.
In adult patients with inborn heart defects this has not yet been researched. Therefore,patients with ventriculoperitoneal shunt, septal and atrio-septal shunt should be examined. Also, patients with chronic obstructive pulmonary disease should be examined.
The aim of this study is the validation of a novel magnet resonance sequence in terms of a distinction of oxygenated blood to deoxygenated blood in comparison to invasive method of measuring cardiac catheterization.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm 1 | Patients with indication for MRI and coronary angiography |
| |
| Arm 2 | Patients with atrioseptal or ventriculoseptal Shunt with indication to coronary angiography |
| |
| Arm 3 | Patients with chronic obstructive pulmonary disease with indication to coronary angiography |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI | Procedure | MRI |
| |
| Measure | Description | Time Frame |
|---|---|---|
| ventricular volumetry | ventricular volumetry by Cardiac Magnet Resonance Imaging using dynamic T2 Preparation Puls for arithmetical determination of end-systolic volume, end-diastolic volume, ejection fraction, stroke volume and myocardial weight | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| oxygen partial pressure | Determination of oxygen partial pressure (pO2) during angiography | baseline |
| carbon dioxide partial pressure | Determination of carbon dioxide partial pressure (pCO2) during angiography |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with atrial septal defect (ASD) or ventricular septal defect (VSD) and COPD, who is planned for MRI and angiography
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| Name | Affiliation | Role |
|---|---|---|
| Britta Butzbach, MD | Heinrich-Heine University, Duesseldorf | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Duesseldorf | Düsseldorf | Germany |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D006345 | Heart Septal Defects, Ventricular |
| D006344 | Heart Septal Defects, Atrial |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Blood
| coronary angiography |
| Procedure |
coronary angiography |
|
| baseline |
| pH-value | Determination of pH-value od blood during angiography | baseline |
| Blood gas analysis | Determination of base excess of blood during angiography | baseline |
| Blood gas analysis | Determination of oxygen partial pressure (pO2), carbon dioxide partial pressure (pCO2), pH-value, base excess | baseline |
| Major adverse cardiac events | Major adverse cardiac events: death, new indication for angiography, hospitalization | 12 month after procedure |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006343 | Heart Septal Defects |
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |