Marker Guided Breathhold Radiotherapy in NSCLC

Proof of Concept Study Evaluating Safety and Performance of a Gel Marker (BioXmark) Used for Image Guidance in Deep Inspiration Breathhold Radiotherapy (DIBH IGRT) in Patients With Locally Advanced Non-small Cell Lung Cancer (NSCLC)

Proof of concept study evaluating safety and performance of a gel marker (BioXmark) used for image guidance in deep inspiration breathhold radiotherapy (DIBH IGRT) in patients with locally advanced non-small cell lung cancer (NSCLC)

Inclusion criteria

• Age > 18 years old
• Histologically confirmed non-small cell lung cancer (NSCLC)
• Stage T1-4N1-3M0
• Performance status ≤ 2
• Inoperable
• FEV1 ≥ 1 l
• Ability to hold deep inspiration breathhold for > 15 seconds
• Accepting treatment at Rigshospitalet
• Eligible for concomitant chemo-radiotherapy
• If a woman is of childbearing potential, a negative pregnancy test must be documented
• Ability to understand the given information
• Signed written consent for inclusion into the study

Exclusion criteria

• Prior thoracic radiotherapy
• Allergy to Iodine or iodine based contrast
• In the opinion of the investigator, the patient will not be able to follow the study procedures or is considered not eligible for other reasons