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Worldwide, the rising incidence of obesity has led to the identification of an obesity related syndrome, called metabolic. This syndrome is characterized by central obesity, hypertension, insulin resistance and altered lipid levels.
Taking into consideration the rising incidence of obesity, anesthetists will more frequently encounter patients with metabolic syndrome, in their everyday practice. Moreover, the comorbidities that are related to the metabolic syndrome, increase the risk for perioperative complications. Therefore, strategies that will evaluate and modify the risk will be of great importance in the management of these patients, in order to maximize peri-anaesthetic and surgical safety.
The aim of the study is to assess the incidence of metabolic syndrome and the impact of its presence on the outcome of patients undergoing elective laparotomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with metabolic syndrome | Patients fulfilling criteria to establish the diagnosis of metabolic syndrome |
| |
| Patients without metabolic syndrome | Patients not fulfilling criteria of the metabolic syndrome |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Elective abdominal surgery | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Perioperative and postoperative adverse cardiac and cerebrovascular events as defined by European Perioperative Clinical Outcome (EPCO) definitions guidelines. | 2 Weeks | |
| Postoperative pulmonary complications as defined by European Perioperative Clinical Outcome (EPCO) definitions guidelines. | 2 Weeks | |
| Acute Kidney Injury (AKI) as defined by Kidney Disease Improving Global Outcomes (KDIGO) guidelines | 2 Weeks | |
| Surgical site infection (superficial or deep) as defined by European Perioperative Clinical Outcome (EPCO) definitions guidelines. | 2 Weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Study population: Adult patients are undergoing elective laparotomy of estimated duration of more than one hour. All operations will be performed under general anesthesia.
Group sample sizes of 42 in group one and 42 in group two achieve 90% power to detect a difference between the group proportions of 0,2500. The proportion in group one (MetS group) is assumed to be 0,0500 under the null hypothesis and 0,3000 under the alternative hypothesis. The proportion in group two (the Non-MetS group) is 0,0500. The test statistic used is the two-sided Likelihood Ratio test. The significance level of the test was targeted at 0,0500. The significance level actually achieved by this design is 0,0909.
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| D009750 |
| Nutritional and Metabolic Diseases |