Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease

Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical Trial

Stem cell transplantation has emerged as a relatively popular treatment that can help to regulate immunity, repair injury, and control inflammation. Several studies have used autologous stem cells or adipose-derived stem cells to treat Crohn's disease and its associated complications, and have achieved good efficacy. Thus far, the use of umbilical cord mesenchymal stem cells (UC-MSCs) to treat Crohn's disease has rarely been reported. In this study, UC-MSCs were used to treat patients with hormone-controlled Crohn's disease. We observed the disease control conditions, corticosteroid dosage changes, and treatment-related adverse reactions.

Inclusion Criteria:

• above 18 years of age
• moderate to severe Crohn's disease (Crohn's disease activity index (CDAI) between 220 and 450)
• had received hormone maintenance therapy for more than 6 months

Exclusion Criteria:

• active tuberculosis
• malignancy
• HIV
• syphilis
• hepatitis B
• hepatitis C