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This study aims to identify clinical and biological markers which would allow to evaluate precisely the evolution of children with autism spectrum disorders throughout intervention.
200 children with autism spectrum disorders (1-12 years old) will be included in a 2 years follow-up study. Both clinical and neurophysiological evaluations (electrophysiological and eye tracking) will be completed at different times of the follow-up. This integrative approach, combining clinical and biological markers, will allow the identification of different developmental trajectories and then a better individuation of treatment in autism spectrum disorders.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| functional rehabilitation of social communication | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical changes between Baseline and Two years | Autism Diagnostic Observation Schedule (ADOS) | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| neurophysiological evaluations at baseline | Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices | baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Children with autism spectrum disorders
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| Name | Affiliation | Role |
|---|---|---|
| Joelle Malvy, MD, PhD | University Hospital, Tours | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University hospital Tours | Tours | 37000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31919663 | Derived | Khanna RK, Kovarski K, Arsene S, Siwiaszczyk M, Pisella PJ, Bonnet-Brilhault F, Batty M, Malvy J. Ophthalmological findings in children with autism spectrum disorder. Graefes Arch Clin Exp Ophthalmol. 2020 Apr;258(4):909-916. doi: 10.1007/s00417-019-04594-7. Epub 2020 Jan 9. |
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| ID | Term |
|---|---|
| D001321 | Autistic Disorder |
| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| neurophysiological evaluations at 1 year |
Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices |
| 1 year |
| neurophysiological évaluations at 2 years | Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices | 2 years |
| Social and cognitive evaluations at baseline | Social and Cognitive Evaluation Battery (SCEB), | baseline |
| Social and cognitive évaluations at 1 year | Social and Cognitive Evaluation Battery (SCEB), | 1 year |
| Social and cognitive évaluations at 2 years | Social and Cognitive Evaluation Battery (SCEB), | 1 year |
| Repetitive behaviors évaluations at baseline | Repetitive and Restrictive Behavior Scale (RRBS) | baseline |
| Repetitive behaviors évaluations at one year | Repetitive and Restrictive Behavior Scale (RRBS) | 1 year |
| Repetitive behaviors at two years | Repetitive and Restrictive Behavior Scale (RRBS) | 2 years |