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Difficulties to recruit on time the required patient population.
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| Name | Class |
|---|---|
| California Institute of Technology | OTHER |
| University of Bern | OTHER |
| Universitaire Ziekenhuizen KU Leuven | OTHER |
Intra-lesion administration of an Endothelin Receptor B inhibitor (BQ-788) or vehicle was preformed in 5 melanoma patients to have a preliminary analysis of safety, dose, duration and relevance of results observed in pre-clinical studies to the human disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endothelin receptor B inhibitor BQ-788 | Experimental | Intra-lesion administration of an Endothelin Receptor B inhibitor (BQ-788) |
|
| PBS | Experimental | Intra-lesion administration of vehicle |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endothelin Receptor B inhibitor BQ788 | Drug |
| ||
| PBS |
| Measure | Description | Time Frame |
|---|---|---|
| Tumour response by size measurement and histological examination | 3 to14 days |
| Measure | Description | Time Frame |
|---|---|---|
| Measuring changes in tumor cell proliferation by histological analyses using Ab staining | 3 to 14 days | |
| Evaluation of changes in mRNA as well as protein expression levels of Endothelin Receptor B by PCR and Ab staining | 3 to 14 days |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8632985 | Background | Lahav R, Ziller C, Dupin E, Le Douarin NM. Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3892-7. doi: 10.1073/pnas.93.9.3892. | |
| 9826680 | Background | Lahav R, Dupin E, Lecoin L, Glavieux C, Champeval D, Ziller C, Le Douarin NM. Endothelin 3 selectively promotes survival and proliferation of neural crest-derived glial and melanocytic precursors in vitro. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14214-9. doi: 10.1073/pnas.95.24.14214. |
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| ID | Term |
|---|---|
| D008545 | Melanoma |
| ID | Term |
|---|---|
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
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| Drug |
|
| Evaluation of changes in blood vessels formation by histological examination using Ab staining | 3 to 14 days |
| Evaluation of changes in immune cell infiltration by histological examination using Ab staining | 3 to 14 days |
| 10500205 | Background | Lahav R, Heffner G, Patterson PH. An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11496-500. doi: 10.1073/pnas.96.20.11496. |
| 15604257 | Background | Lahav R, Suva ML, Rimoldi D, Patterson PH, Stamenkovic I. Endothelin receptor B inhibition triggers apoptosis and enhances angiogenesis in melanomas. Cancer Res. 2004 Dec 15;64(24):8945-53. doi: 10.1158/0008-5472.CAN-04-1510. |
| 15906230 | Background | Lahav R. Endothelin receptor B is required for the expansion of melanocyte precursors and malignant melanoma. Int J Dev Biol. 2005;49(2-3):173-80. doi: 10.1387/ijdb.041951rl. |
| 26330458 | Derived | Wouters J, Hunger RE, Garrod T, Dubuis B, Hunziker T, van den Oord JJ, Lahav-le Coutre R. First-in-Human Proof-of-Concept Study: Intralesional Administration of BQ788, an Endothelin Receptor B Antagonist, to Melanoma Skin Metastases. Oncologist. 2015 Oct;20(10):1121-2. doi: 10.1634/theoncologist.2015-0139. Epub 2015 Sep 1. |
| D009369 | Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
| D018326 | Nevi and Melanomas |
| D012878 | Skin Neoplasms |
| D009371 | Neoplasms by Site |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |