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The purpose of this study is to evaluate biomarkers affecting the hemodynamic responses to propofol. Particularly, the investigators will assess the effects of polymorphisms in NOS3 and PRKCA genes on hemodynamic responses to propofol and the effects of these polymorphisms on biomarkers related to nitric oxide after propofol anesthesia. In addition, the investigators will evaluate the effects of propofol anesthesia on biomarkers related to nitric oxide in hypertensive patients chronically treated with angiotensin-converting enzyme inhibitors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normotensive | |||
| Hypertensive taking ACEi | |||
| Hypertensive not taking ACEi |
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| Measure | Description | Time Frame |
|---|---|---|
| Systolic blood pressure | 10 minutes | |
| Diastolic blood pressure | 10 minutes | |
| Mean blood pressure | 10 minutes | |
| Heart rate | 10 minutes | |
| Plasma nitrite levels | 10 minutes | |
| Plasma nitrate levels | 10 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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Patients under propofol anesthesia
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33410970 | Derived | Oliveira-Paula GH, Coeli-Lacchini FB, Ferezin LP, Ferreira GC, Pinheiro LC, Paula-Garcia WN, Garcia LV, Tanus-Santos JE, Lacchini R. Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability. Eur J Clin Pharmacol. 2021 Jun;77(6):869-877. doi: 10.1007/s00228-020-03059-9. Epub 2021 Jan 7. |
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