neoMONARCH: A Phase 2 Neoadjuvant Trial Comparing the Biological Effects of 2 Weeks of Abemaciclib (LY2835219) in Combination With Anastrozole to Those of Abemaciclib Monotherapy and Anastrozole Monotherapy and Evaluating the Clinical Activity and Safety of a Subsequent 14 Weeks of Therapy With Abemaciclib in Combination With Anastrozole in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast Cancer
neoMONARCH: A Phase 2 Neoadjuvant Trial Comparing the Biological Effects of 2 Weeks of Abemaciclib (LY2835219) in Combination With Anastrozole to Those of Abemaciclib Monotherapy and Anastrozole Monotherapy and Evaluating the Clinical Activity and Safety of a Subsequent 14 Weeks of Therapy With Abemaciclib in Combination With Anastrozole in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast Cancer
The purpose of this study is to evaluate the biological effects of abemaciclib in combination with anastrozole and compare those to the effects of abemaciclib alone and anastrozole alone in the tumors of postmenopausal women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 (HER2) negative breast cancer.
Inclusion Criteria:
Exclusion Criteria:
Graz, 8036, Austria
Innsbruck, 6020, Austria
Vienna, 1090, Austria
Edegem, 2650, Belgium
Hasselt, 3500, Belgium
Namur, 5000, Belgium
Yvoir, 5530, Belgium
Montreal, H4A 3J1, Canada
Ottawa, K1H 8L6, Canada
Berlin, 13125, Germany
Erlangen, 91054, Germany
Essen, 45136, Germany
Esslingen am Neckar, 73730, Germany
Freiburg im Breisgau, 79106, Germany
Fürth, 90766, Germany
Heidelberg, 69120, Germany
Ludwigsburg, 71640, Germany
Tübingen, 72076, Germany
Ulm, 89075, Germany
Milan, 20141, Italy
Naples, 80131, Italy
Padova, 35128, Italy
Piacenza, 29121, Italy
Maastricht, 6229 HX, Netherlands
Rotterdam, 3015 GD, Netherlands
Daegu, 41404, South Korea
Gangnam-gu, 06351, South Korea
Seodaemun-gu, 03722, South Korea
Seongbuk-gu, 02841, South Korea
Seongnam, 13496, South Korea
Songpa-gu, 05505, South Korea
Ulsan, 44033, South Korea
Badajoz, 06080, Spain
Lleida, 25198, Spain
Madrid, 28034, Spain
Málaga, 29010, Spain
Changhua, 500, Taiwan
Taichung, 40447, Taiwan