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QT interval changes is measured during all phases of the operation. The protocol is focusing at intraoperative bleeding events and is also observing QT interval changes during anesthetic and operative procedures.
Prolongation of the QT interval is associated with functional torsade de points, re-entry, and sudden death (see reference). Variations of QT-interval caused by changes in the volume status of the patient during an operation remained unclear. QT interval changes will be monitored during the surgery with the focus of the influence of sudden blood loss, volume substitution by crystalloids, blood and blood products. The effect of surgical procedures on the QT-interval (e.g. clamping of kidney artery) will be observed as well as the association of intra-operative QT-interval alterations with postoperative complications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| bleeding | intraoperative blood loss > 500 ml |
| |
| no bleeding | intraoperative blood loss < 500 ml |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intra-operative blood loss | Procedure | surgery in the urology and orthopedics |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in QT-time | during operation |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative incidents/disturbance rhythm of the heart | association to intraoperative repolarisation-disturbance / QT-prolongation | 2 days |
| survival | association to intraoperative repolarisation-disturbance / QT-prolongation |
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Inclusion Criteria:
Exclusion Criteria:
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patients for major surgery in urology and orthopedics
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Torsten Richter, M.D. | Contact | 004935145818034 | torsten.richter@uniklinikum-dresden.de | |
| Juliane Flaxa, M.D. | Contact | 0049351458 | 2785 | juliane.flaxa@uniklinikum-dresden.de |
| Name | Affiliation | Role |
|---|---|---|
| Torsten Richter, M.D. | University Hospital Dresden, TU Dresden | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of Anesthesia and Intensive Care, University Hospital, Technische Universität Dresden | Recruiting | Dresden | 01307 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16412861 | Background | Straus SM, Kors JA, De Bruin ML, van der Hooft CS, Hofman A, Heeringa J, Deckers JW, Kingma JH, Sturkenboom MC, Stricker BH, Witteman JC. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol. 2006 Jan 17;47(2):362-7. doi: 10.1016/j.jacc.2005.08.067. |
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| ID | Term |
|---|---|
| D016063 | Blood Loss, Surgical |
| D006470 | Hemorrhage |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007431 | Intraoperative Complications |
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| 1 year |