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Nowadays Cesarean sections became the most popular surgery worldwide with the consumption of the hospital resources and the continuous need to decrease the costs, work load and medical stuff engagement. One of the most common problem is the need to control pain post operatively, this issue increase the work load over the pain management team and increase lead to patient in satisfaction.
This study will test the usage of dexamethasone with different doses (4 and 8 mg) either locally or intravenously (I.V.) with the local anesthetics in TAP (transversus abdominis plane) block to prolong the duration of the block and decrease the need of post-operative analgesics.
Nowadays Cesarean sections became the most popular surgery worldwide with the consumption of the hospital resources and the continuous need to decrease the costs, work load and medical stuff engagement. One of the most common problem is the need to control pain post operatively, this issue increase the work load over the pain management team and increase lead to patient in satisfaction.(1,2,3) The presence of the adjuvant which can be added to the conventional anesthetic medications can prolong the duration of action and decrease the need for frequent post-operative analgesics.(4,5) The idea of adding a catheter or placing an epidural catheter still have a quite limitation regarding the patients compliance, delayed ambulation and high costs, these limitations redirect the anesthetist again to the use of adjuvant with a single shot block to prolong the duration of it and decrease the need of subsequent analgesics.(6) Dexamethasone proved to be an effective adjuvant in prolongation of the nerve blocks with the question regarding the proper route and dose (7,8,9,10).
This study will test the usage of dexamethasone with different doses (4 and 8 mg) either locally or intravenously (I.V.) with the local anesthetics in TAP (transversus abdominis plane) block to prolong the duration of the block and decrease the need of post-operative analgesics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CONTROL | Placebo Comparator | TAP block without Dexamethasone neither intravenous nor in combination with the block |
|
| Group 2 (TD8IS) | Experimental | Dexamethasone in combination with TAP block in dose of 8 mg |
|
| Group 3(TD4IS) | Experimental | Dexamethasone in addition to TAP block in dose of 4 mg |
|
| Group 4 (TSID8): | Experimental | Dexamethasone intravenous in addition to TAP block in dose of 8 mg |
|
| Group5(TSID4) | Experimental | Dexamethasone intravenous 4mg+ TAP block |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexamethasone in addition to TAP block in dose of 4 mg | Drug | Dexamethasone in addition to TAP block in dose of 4 mg |
|
| Measure | Description | Time Frame |
|---|---|---|
| level of pain according to verbal analogue scale | THREE DAYS |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hassan Ali | Contact | +201001733687 | hassan364@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Hassan Ali, LECTURER | Anesthesia department, faculty of medicine ,Cairo university | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University | Recruiting | Cairo | Giza Governorate | 1234 | Egypt |
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| Dexamethasone in combination with TAP block in dose of 8 mg | Drug | Dexamethasone in combination with TAP block in dose of 8 mg |
|
| Dexamethasone intravenous 4mg+ TAP block | Drug | Dexamethasone intravenous in addition to TAP block in dose of 4 mg |
|
|
| Dexamethasone intravenous in addition to TAP block in dose of 8 mg | Drug | Dexamethasone intravenous + TAP block in dose of 8 mg |
|
|
| control | Other | TAP block without Dexamethasone neither intravenous nor in combination with the block |
|
|
| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
| D008722 | Methods |
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