The purpose of this phase II is to study the efficacy and toxicity of carboplatin and paclitaxel with pertuzumab and trastuzumab in HER2 positive and carboplatin and paclitaxel with bevacizumab in HER2 negative in the neoadjuvant setting for the treatment of breast cancer.

OBJECTIVES The study component is to evaluate the treatment response and toxicity of the protocol.

Objectives for treatment study component:

1.1 To estimate 2-year progression-free survival in patients with breast cancer with tumor more than 1 cm and/or with clinically detected lymph node treated with neoadjuvant weekly Carboplatin and Paclitaxel combined with Trastuzumab + Pertuzumab in HER2-positive disease or with Bevacizumab in HER2-negative disease.

1.2 To measure the microscopic complete pathological response (pCR) rates defined as ypT0 or ypTis tumors in patients treated with this regimen in the neoadjuvant setting.

1.3 To assess complete clinical response (cCR) rates after treatment by physical exam and imaging tests (ultrasonography, mammography, or magnetic resonance imaging) clinical objective response rate (by Response Evaluation Criteria In Solid Tumors (RECIST)) 1.4 To determine the toxicity of this regimen. 1.5 To determine treatment adherence and delivered dose intensity of this regimen.

1.6 To assess the correlation between pCR and cCR. 1.7 To determine the rate of breast conservation following neoadjuvant therapy. 1.8 Determine treatment efficacy according to subgroups defined according to stage and receptor status.

Inclusion Criteria:

1. Histologically proven unilateral or bilateral primary breast carcinoma. (In case of bilateral cancer, the investigator has to decide prospectively which side will be evaluated for the primary endpoint.)

2. Tumor size is clinically at least 1 cm in greatest diameter (palpable or by imaging) and/or with involved lymph node. In case of inflammatory disease, the extent of inflammation may be the measurable lesion.

3. Documentation of inflammatory breast cancer

4. Woman age > or = 18

5. Performance status of 0-2 by Eastern Cooperative Oncology Group (ECOG) criteria

6. Known HER2 status

7. Normal cardiac function must be documented within 90 days prior to registration either via an ECHO or MUGA or per physician's review of symptoms and medical history. If an ECHO is performed as standard of care, the ejection fraction must be above the normal limit of the institution.. If not available in the medical chart, the ECHOs or MUGAs are not required to be repeated for research purposes.

   a. Date of Echo or multigated acquisition (MUGA) (within 90 days) if performed

8. Staging work-up prior to registration

   1. Date of physical examination (within 90 days)
   2. Date of bilateral mammogram (within 90 days)
   3. Date of breast ultrasound (within 90 days)
   4. Date of MRI breast (within 30 days)
   5. Chest X-ray or CT- Chest or CT/PET Scan that includes the Chest may be done at physician's discretion (within 90 days). If not available in the medical chart, the Chest X-ray or CT- Chest or CT/PET Scan that includes the Chest is not required to be repeated for research purposes.
   6. Other tests as clinically indicated

9. Laboratory requirements:

   1. Hematology:

      • Absolute Neutrophil Count (ANC) ≥ 1,500/μl
      • Platelets ≥ 100,000/μl

   2. Hepatic Function

      • Total Bilirubin <1x upper limit of normal (ULN)
      • aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2x ULN

   3. Renal Function

      - Creatinine <1.5x ULN

   4. Proteinuria

      - Random urine total protein <100mg/dL. Urine Protein Creatinine (UPC) ratio <2g

   5. Negative pregnancy test for women of childbearing potential within 14 days prior to registration.

10. All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.

    Exclusion Criteria:

11. Evidence of distant metastasis. If radiographic suspicion of distant metastatic site, a negative biopsy must be available in the medical record. If not available in the medical record, the subject may be included and a confirmatory biopsy is not required to be performed for research purposes.

12. Known or suspected congestive heart failure, angina pectoris requiring antianginal medication, or other clinically significant cardiac condition.

13. Pregnant or nursing women may not participate due to the possibility of harm to fetus or nursing infants from this treatment regimen. Women of childbearing potential may not participate unless they have agreed to use an adequate contraceptive method throughout study treatment and for one month after completion of treatment.

14. Male patients

15. Pre-existing peripheral neuropathy of severity grade ≥ 2 (limiting instrumental activities of daily living).

16. Incomplete wound healing.

17. Active and significant bleeding

18. Known allergy, hypersensitivity or prior infusion reaction to one or more of the therapies incorporated into this treatment protocol.

19. Bone marrow depression or hematologic parameters in the range that would increase the risk for severe bleeding.