Botulinum Toxin-A as a Treatment for Chronic Muscle-Related Pain in Adults With Spastic Cerebral Palsy: a Randomized Controlled Trial

Botulinum Toxin-A as a Treatment for Chronic Muscle-Related Pain in Adults With Spastic Cerebral Palsy: a Randomized Controlled Trial

The purpose of this double-blinded, placebo-controlled study is to test if treatment with Botulinum toxin-A is effective in reducing chronic muscle-related pain in adults with spastic cerebral palsy.

Inclusion Criteria:

• Age ≥ 18 years.
• Spastic Cerebral Palsy.
• Chronic pain, related to spastic muscle. Chronic pain defined as: 1)Recurring regional pain for at least three months AND 2)Pain intensity on average for the last 24 hours ≥3 on Numerical Rating Scale.
• Signed Informed consent.

Exclusion Criteria:

• Allergy/hypersensitivity to Dysport® or any of its components.
• Pregnancy.
• Women who breastfeed their children.
• Treatment with Botulinum toxin-A within the last five months.
• If there has been dose changes in any muscle-tone altering medication within two weeks of Visit 1.
• A clear degenerative cause behind the pain as elucidated by the clinical examination (e.g. history of osteoarthritis).
• Intellectual disability and/or communication impairment that disable the individual from answering the questionnaires and giving informed consent.