Ketamine in Refractory Convulsive Status Epilepticus

Efficacy of Ketamine in Refractory Convulsive Status Epilepticus in Children: a Multicenter, Randomized, Controlled, Open-label, No-profit, With Sequential Design Study.

To evaluate the efficacy of intravenous administration of ketamine in the treatment of refractory convulsive status epilepticus in children compared to administration of midazolam at high doses, thiopental and / or propofol.

Inclusion Criteria:

• Diagnosis and clinical EEGrafica of refractory convulsive status epilepticus
• Refractoriness of the drug I and II line
• Written informed consent from parents or legal guardian.
• Administration of rating scales in the risk of mortality (PIM III) and severity of SE (stess, status epilepticusseverity score) to be performed prior to randomization.

Exclusion Criteria:

• contraindications to the use of the medication/s in the study.
• pregnant or suspected pregnant.