Effect of Remifentanil on Hemodynamic Stability During Placement of a Mayfield Head Fixation Device for Craniotomy

Effect of Remifentanil Administration on Hemodynamic Stability During Placement of a Mayfield Head Fixation Device for Craniotomy

To identify a better method using a combination of routine anesthetic drugs to improve hemodynamic stability during Mayfield head pinning for craniotomy surgery.

A randomized, placebo-controlled, double-blinded comparative effectiveness study to test hypothesis that addition of remifentanil bolus to a standard anesthetic drug regimen will better attenuate the hemodynamic response to the noxious stimulus of Mayfield head pin insertion than the standard anesthetic drug regimen.

Inclusion Criteria:

• Adult non-pregnant patients
• undergoing general anesthesia for a craniotomy
• requiring a Mayfield head fixation device.

Exclusion Criteria:

• Patients under 18 years of age,
• non-English speaking,
• pregnancy,
• opioid tolerance,
• illegal drug use or alcohol abuse.