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| ID | Type | Description | Link |
|---|---|---|---|
| 15/LO/0081 | Other Identifier | Research Ethics Committee | |
| 166784 | Other Identifier | IRAS | |
| R&D2015/017 | Other Identifier | R&D office |
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This is a feasibility trial designed to test the feasibility and acceptability of a brief form (six sessions) of Cognitive Behavioural Therapy (CBT) for Depersonalisation/Derealisation (DP/DR) in those individuals who also have a diagnosis of a psychotic disorder. Participants will be randomised to receive either six sessions of CBT targeting DP/DR symptoms or to a treatment as usual control condition.
Depersonalisation/derealisation (DP/DR) are distressing symptoms of having a sense of detachment and unreality about oneself (DP) or the external world (DR). Cognitive Behavioural Therapy (CBT) has been found to be beneficial in treating patients with chronic DP/DR. CBT for DP/DR includes educating patients about these experiences so they have a better understanding and less fear; teaching ways of coping to help them manage the symptoms better; helping reduce the impact on their day to day functioning; and working together to find less distressing ways of interpreting these experiences. Recent research has highlighted that DP/DR symptoms are common in people diagnosed with psychotic disorders, and when present are linked with more severe psychotic symptoms. However, there has been no previous study to ascertain if CBT to target DP/DR in psychosis would be effective. This study therefore aims to establish the feasibility of a brief CBT intervention for DP/DR in people diagnosed with a psychotic disorder. It is hoped that the CBT will reduce the distress associated with DP/DR experiences, with a possibility of reducing psychotic phenomena in addition. The investigators will seek to recruit adults aged 18-70 with a current psychotic symptoms as well as meeting threshold for DP/DR disorder. Participants will be randomly assigned to receive six sessions of CBT or to a treatment as usual control. Outcomes will be assessed at baseline and follow-up interview at 10 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CBT for DP | Active Comparator | Six sessions of CBT covering psycho-education, formulation, enhancing coping strategies (including grounding) and cognitive restructuring techniques. |
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| Treatment as usual | Placebo Comparator | Participants will continue to receive their normal treatment - in most cases, this will be care coordination/case management delivered through a community mental health team and may include medication. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CBT for Depersonalization/Derealization | Other | In addition to treatment as usual, six sessions of Cognitive Behavioural Therapy for Depersonalization/Derealisation covering psychoeducation, formulation, coping strategies. |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of intervention ( including recruitment rates, acceptance rates, drop outs) | Feasibility estimates of delivering the intervention including recruitment rates, acceptance rates, drop outs. | 10 weeks |
| Depersonalisation score (Score on the Cambridge Depersonalisation Scale) | Score on the Cambridge Depersonalisation Scale | 10 weeks |
| Acceptability of intervention (Satisfaction and attrition rates) | Satisfaction and attrition rates | 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Depression (Score on Beck Depression Inventory) | Score on Beck Depression Inventory | 10 weeks |
| Anxiety (Score on Beck Anxiety Inventory) | Score on Beck Anxiety Inventory |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Simone Farrelly, PhD | King's College London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| PICUP clinic | London | London | SE5 8AZ | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37716893 | Derived | Farrelly S, Peters E, Azis M, David AS, Hunter ECM. A brief CBT intervention for depersonalisation-derealisation disorder in psychosis: Results from a feasibility randomised controlled trial. J Behav Ther Exp Psychiatry. 2024 Mar;82:101911. doi: 10.1016/j.jbtep.2023.101911. Epub 2023 Sep 12. | |
| 27965864 | Derived |
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| ID | Term |
|---|---|
| D011618 | Psychotic Disorders |
| D003861 | Depersonalization |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| Treatment as usual | Other | Treatment as usual - in most cases case management/care coordination and may include medication |
|
| 10 weeks |
| Psychosis (Score on the Psychotic Symptom Rating Scale (PSYRATS) | Score on the Psychotic Symptom Rating Scale (PSYRATS) | 10 weeks |
| Farrelly S, Peters E, Azis M, David A, Hunter EC. A brief CBT intervention for depersonalisation/derealisation in psychosis: study protocol for a feasibility randomised controlled trial. Pilot Feasibility Stud. 2016 Aug 11;2:47. doi: 10.1186/s40814-016-0086-7. eCollection 2016. |