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A multiple-dose, double-blind, randomized, four-week, three-treatment, parallel study in which 66 healthy adult subjects will receive 6 capsules/d, administered as a dose of 1.3 g/d eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) in fish oil ethyl ester (EE), or fish oil triglyceride (TG) or krill oil for a total of 4 weeks. The objective of the study is to compare the oral bioavailability of EPA+DHA in total plasma across the three formulations at the end of the 4 week study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| fish oil ethyl ester | Active Comparator | 1.3g/d dose of DHA+EPA in fish oil EE (6 capsules) administered for 4 weeks |
|
| fish oil triglyceride | Active Comparator | 1.3g/d dose of DHA+EPA in fish oil TG (6 capsules) administered for 4 weeks |
|
| krill oil | Active Comparator | 1.3g/d dose of DHA+EPA in krill oil (6 capsules) administered for 4 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fish oil ethyl ester | Dietary Supplement |
| ||
| fish oil triglyceride |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of total plasma DHA+EPA levels across 3 treatment groups | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of RBC DHA+EPA levels across 3 treatment groups | 4 weeks | |
| pharmacokinetic parameter: AUC to 672hr | 4 weeks | |
| pharmacokinetic parameter: AUC to 336hr |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Vanessa Smeberg, MD | Worldwide Clinical Trials | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26328782 | Derived | Yurko-Mauro K, Kralovec J, Bailey-Hall E, Smeberg V, Stark JG, Salem N Jr. Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study. Lipids Health Dis. 2015 Sep 2;14:99. doi: 10.1186/s12944-015-0109-z. |
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| Dietary Supplement |
|
| krill oil | Dietary Supplement |
|
| 2 weeks |
| pharmacokinetic parameter: Cmax | 4 weeks |
| pharmacokinetic parameter: Tmax | 4 weeks |