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The objective of this study is to determine the impact of consuming MREs as the sole source of subsistence for 21 days on gut bacteria community composition and gut health. Up to 80 free-living adults will be randomized to consume their usual diet or only MREs for 21 consecutive days. MREs will be provided by the Military Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM). Fecal, urine and blood samples will be collected periodically before, during and after the intervention to measure gut barrier integrity, gut bacteria community composition, and markers of gut health, inflammation, and nutritional status.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | Usual diet | |
| MRE | Experimental | MRE consumption |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRE | Other | MRE consumption |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in gut barrier integrity | Urine excretion of saccharide probes; circulating zonulin, intestinal fatty acid binding protein, claudin-3, lipopolysaccharide and GLP2 concentrations | Baseline to 10 days, 21 days and 31 days |
| Measure | Description | Time Frame |
|---|---|---|
| Change in gut microbiota composition | 16S rRNA gene sequencing | Baseline to 10 days, 21 days and 31 days |
| Change in C-reactive protein concentrations | Serum C-reactive protein |
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Inclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| USARIEM | Natick | Massachusetts | 01760 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36774101 | Derived | Karl JP, Armstrong NJ, Player RA, Rood JC, Soares JW, McClung HL. The Fecal Metabolome Links Diet Composition, Foacidic positive ion conditions, chromatographicallyod Processing, and the Gut Microbiota to Gastrointestinal Health in a Randomized Trial of Adults Consuming a Processed Diet. J Nutr. 2022 Nov;152(11):2343-2357. doi: 10.1093/jn/nxac161. Epub 2022 Jul 26. | |
| 36707764 |
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| Baseline to 10 days, 21 days and 31 days |
| Change in TNF-alpha concentrations | Serum TNF-alpha | Baseline to 10 days, 21 days and 31 days |
| Change in interleukin-6 concentrations | Serum IL-6 | Baseline to 10 days, 21 days and 31 days |
| Change in lipopolysaccharide concentrations | Plasma LPS | Baseline to 10 days, 21 days and 31 days |
| Change in iron status | Blood ferritin, soluble transferrin receptor, hemoglobin, hematocrit | Baseline to 10 days, 21 days and 31 days |
| Change in vitamin D status | Blood 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone | Baseline to 10 days, 21 days and 31 days |
| Change in B-vitamin status | Blood folate, vitamin B12, homocysteine | Baseline to 10 days, 21 days and 31 days |
| Change in nutritional status | Blood prealbumin | Baseline to 10 days, 21 days and 31 days |
| Change in calcium absorption | Urine calcium | Baseline to 10 days, 21 days and 31 days |
| Change in zinc status | Blood zinc, zinc receptor expression | Baseline to 10 days, 21 days and 31 days |
| Pantoja-Feliciano IG, Karl JP, Perisin M, Doherty LA, McClung HL, Armstrong NJ, Renberg R, Racicot K, Branck T, Arcidiacono S, Soares JW. In vitro gut microbiome response to carbohydrate supplementation is acutely affected by a sudden change in diet. BMC Microbiol. 2023 Jan 28;23(1):32. doi: 10.1186/s12866-023-02776-2. |
| 32828737 | Derived | McClung HL, Armstrong NJ, Hennigar SR, Staab JS, Montain SJ, Karl JP. Randomized Trial Comparing Consumption of Military Rations to Usual Intake for 21 Consecutive Days: Nutrient Adequacy and Indicators of Health Status. J Acad Nutr Diet. 2020 Nov;120(11):1791-1804. doi: 10.1016/j.jand.2020.06.018. Epub 2020 Aug 19. |