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| Name | Class |
|---|---|
| Research Institute for Genetic and Human Therapy | OTHER |
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50 periodontitis 50 healthy individuals serological evaluation will done to see association of 77A/G AND 11A/12A gene polymorphisms of MMP-13
The study will be conducted on 100 individuals
50 chronic periodontitis and 50 healthy individuals will be recruited from the Out Patient Department of Periodontics in the study.
An informed consent will be obtained from patients who wish to participate in the study.
Patients will be categorized by Periodontal Disease Index (PDI) by P. Ramfjord(1959)
After clinical examination, blood samples will be collected and assessed for MMP 13 Gene Polymorphisms.
Subjects will be selected according to the study criteria and divided into two groups (50 each).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| test | 50 periodontitis patients • Patients will be categorized by Periodontal Disease Index (PDI) by P. Ramfjord(1959) blood samples collected from all patients serum separated and evaluated for77A/G AND 11A/12A associated gene polymorphism of Matrix Metallo Proteinase( MMP)-13 in all the patients. studies showing that there is co relation of these genes with increase inflammation. |
| |
| control | 50 periodontally healthy individuals blood samples collected from all patients serum separated and evaluated for77A/G AND 11A/12A associated gene polymorphism of Matrix Metallo Proteinase (MMP)-13 in all the patients |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood samples collected from all patients | Genetic | blood samples collected from brachial pluxes |
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| Measure | Description | Time Frame |
|---|---|---|
| to evaluate the association of 77A/G AND 11A/12A gene polymorphism of mmp-13 in periodontitis effected and healthy individuals | collect DNA samples from serum and evaluate for gene polymorphism | 6 months |
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Inclusion Criteria:• Test group
Patients with chronic periodontitis classified according to American Academy of Periodontology ( AAP) 1999
Subjects aged between 30-55 years
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19453573 | Background | Pirhan D, Atilla G, Emingil G, Tervahartiala T, Sorsa T, Berdeli A. MMP-13 promoter polymorphisms in patients with chronic periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therapy. J Clin Periodontol. 2009 Jun;36(6):474-81. doi: 10.1111/j.1600-051X.2009.01399.x. Epub 2009 Apr 22. | |
| 9626053 | Result |
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blood serum
| Uitto VJ, Airola K, Vaalamo M, Johansson N, Putnins EE, Firth JD, Salonen J, Lopez-Otin C, Saarialho-Kere U, Kahari VM. Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation. Am J Pathol. 1998 Jun;152(6):1489-99. |
| 11940142 | Result | Kiili M, Cox SW, Chen HY, Wahlgren J, Maisi P, Eley BM, Salo T, Sorsa T. Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue. J Clin Periodontol. 2002 Mar;29(3):224-32. doi: 10.1034/j.1600-051x.2002.290308.x. |
| 19929954 | Result | Hernandez Rios M, Sorsa T, Obregon F, Tervahartiala T, Valenzuela MA, Pozo P, Dutzan N, Lesaffre E, Molas M, Gamonal J. Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade. J Clin Periodontol. 2009 Dec;36(12):1011-7. doi: 10.1111/j.1600-051X.2009.01488.x. |