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| ID | Type | Description | Link |
|---|---|---|---|
| 12C14NL | Other Grant/Funding Number | World Anti-doping Agency |
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The aim of the proposed project is to perform a clinical study in which volunteers will receive autologous blood transfusions in DEHP-free blood bags.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Blood bags without DEHP | Experimental | Intervention : Autologous blood transfusion |
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| Blood bags with DEHP | Experimental | Intervention : Autologous blood transfusion |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Autologous blood transfusion | Biological | Volunteers make a blood donation and after 36 days of storage this blood is re-infused in the same volunteers. |
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| Measure | Description | Time Frame |
|---|---|---|
| Measurement of blood parameters profile, iron metabolism and genomic compounds | Blood profiling such as measurement of concentration of different blood cells and hemoglobin will be measured up to 15 days after blood-reinfusion. Concentration of free-iron, ferritin and hepcidin will be measured in plasma and serum up to 15 days after blood re-infusion. Concentration of circulating microRNAs will be measured in plasma also up to 15 days after blood re-infusion. All measures are compared. | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nicolas Leuenberger, PhD | Swiss Laboratory for Doping Analyses | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Swiss Laboratory for Doping Analyses | Épalinges | Canton of Vaud | 1066 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26822428 | Derived | Leuenberger N, Barras L, Nicoli R, Robinson N, Baume N, Lion N, Barelli S, Tissot JD, Saugy M. Hepcidin as a new biomarker for detecting autologous blood transfusion. Am J Hematol. 2016 May;91(5):467-72. doi: 10.1002/ajh.24313. Epub 2016 Apr 6. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Sep 23, 2015 | |
| Unrelease | Yes | |
| Release | Sep 28, 2015 | |
| Reset | Oct 28, 2015 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Sep 23, 2015 | Yes | |||
| Sep 28, 2015 |
| ID | Term |
|---|---|
| D065227 | Transfusion Reaction |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D001804 | Blood Transfusion, Autologous |
| ID | Term |
|---|---|
| D001803 | Blood Transfusion |
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
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| Oct 28, 2015 |