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| Name | Class |
|---|---|
| University of Washington | OTHER |
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This is a case/control epidemiology study to identify what are the iron-metabolism abnormalities in Parkinson's disease (PD) patients, and risk factors relevant to PD predisposition.
A total of 342 participants, 100 PD patients and 242 age- and gender matched controls, were included in the study. All study participants were seen for one study visit in the morning at one of two Bastyr University Clinics in the Seattle area. Study participants were fasting at the time of the visit. During the study visit, participants donated a blood sample for the blood tests and complete an epidemiology questionnaire.
A subset of 51 of the study participant who were seen for the visit at Bastyr University, underwent brain scan and Magnetic Resonance Imaging (MRI), at the University of Washington Department of Radiology. The MRI part of the study aims at estimating brain iron levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PD | 100 PD patients were patients diagnosed with Parkinson's disease | ||
| Controls | 242 Controls were subjects free of neurodegenerative diseases, matched by age and gender to the PD patients |
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| Measure | Description | Time Frame |
|---|---|---|
| Iron metabolism differences between PD patients and controls | Iron metabolism will be measured by testing for serum iron and iron-binding proteins, and by estimating brain iron by MRI. Serum iron parameters that will be measured include total serum iron, iron-binding proteins such as transferrin and ferritin, and tests related to iron metabolism: transferrin % saturation, unsaturated iron binding capacity, soluble transferrin receptor, complete blood count, hemoglobin, uric acid, haptoglobin, haptoglobin phenotype. Differences in serum iron parameters, and brain iron levels, between PD patients and controls will be calculated. | Up to 7 years |
| Measure | Description | Time Frame |
|---|---|---|
| Environmental factors affecting PD risk and gene-environment interactions | Questionnaire data will be analyzed to identify risk factors for PD by comparing lifestyle and dietary patterns from questionnaire between PD cases and controls. Interaction between haptoglobin phenotype and tobacco smoking on PD risk will be calculated, as well as interaction between haptoglobin phenotype and environmental factors such as tobacco smoking and diet on serum iron and brain iron levels. |
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Inclusion Criteria for the Controls, for the blood draw and epidemiology visit:
Exclusion Criteria for the Controls:
Inclusion Criteria for the Parkinson's disease patients:
Diagnosis of Parkinson's disease (UKBB clinical criteria).
Exclusion criteria for the Parkinson's disease patients, for the blood draw and epidemiology visit:
Exclusion criteria for the Magnetic Resonance Imaging:
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Parkinson's disease patients will be included in the study if they received a diagnosis of Parkinson's disease that meets the United Kingdom Brain Bank (UKBB) clinical criteria of Parkinson's disease diagnosis.
Control participants will be included in the study if free of neurodegenerative diseases.
A subset of the study participants (60 total) receive Magnetic Resonance Imaging to estimate brain iron
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| Name | Affiliation | Role |
|---|---|---|
| Paola Costa-Mallen, PhD | Bastyr University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California | San Diego | California | 92093 | United States | ||
| Bastyr University Research Institute |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17918239 | Background | Costa-Mallen P, Checkoway H, Zabeti A, Edenfield MJ, Swanson PD, Longstreth WT Jr, Franklin GM, Smith-Weller T, Sadrzadeh SM. The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet. 2008 Mar 5;147B(2):216-22. doi: 10.1002/ajmg.b.30593. |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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We collect serum and plasma samples during the study, that were tested for total serum iron and iron-binding proteins.
| recruitment until January 2016 |
| Kenmore |
| Washington |
| 98028 |
| United States |
| University of Washington | Seattle | Washington | 98195 | United States |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |