Sugammadex and Cognitive Function

Effect of Sugammadex Versus Neostigmine/Atropine Combination on Cognitive Function After Elective Adult Surgery

Post operative cognitive dysfunction (POCD) is recognized as a frequent complication after both cardiac and non cardiac surgery, affecting approximately 1/3 of the patients. The aim of this study is to examine the possible effect of the novel reversal agent sugammadex versus neostigmine/ atropine combination on cognitive function of adult patients after elective surgery during the early post operative period as well as at discharge.

Inclusion Criteria:

• Patients aged >40 years old
• ASA I-III
• Patients scheduled for elective surgery with general anaesthesia.

Exclusion Criteria:

• Neuro-, vascular-, orthopedic- or cardiac surgery
• Known psychiatric or disease of the CNS
• History of craniotomy
• Receiving tranquillisers or antidepressants on a regular basis pre-operatively
• Alcoholism or drug dependence
• History of stroke
• Refusal of patient
• Inability to read or write
• MMSE < 22 pre-operatively