Routine Hysteroscopy in IVF/ICSI Cycles in Patients With Primary Unexplained Infertility

Routine Hysteroscopy in IVF/ICSI Cycles in Patients With Primary Unexplained Infertility: A Randomized Control Trial

The aim of the present study is to evaluate the impact of hysteroscopy prior to starting the IVF (in vitro fertilisation) cycle on treatment outcome in women with unexplained primary infertility.

Proper history, examination and investigations are carried out to diagnose causes of infertility. Office hysteroscopy will be performed during the Luteal phase of the proceeding menstrual cycle using a rigid hysteroscope. Controlled ovarian hyper stimulation-embryo transfer (COH-ET) using the standard long protocol of induction used in Ain Shams University Maternity Hospitals ART (assisted reproductive techniques) unit.

Biochemical pregnancy will be determined by a positive pregnancy test performed 2 weeks after embryo transfer and clinical pregnancy will be defined by the presence of a gestational sac using transvaginal ultrasound performed 6 weeks after embryo transfer.

Inclusion Criteria:

• Patients undergoing IVF/ICSI using the standard long GnRH-a (gonadotropin-releasing hormone-a) protocol.
• No evidence of uterine pathology by transvaginal ultrasound and hysterosalpingography during the follicular phase.
• Patients with unexplained primary infertility.

Exclusion Criteria:

• Patients undergoing IVF using other protocols of induction.
• Patients with evidence of uterine pathology by transvaginal ultrasound or hysterosalpingography during the follicular phase.
• Other causes of infertility rather than unexplained factor.
• Unexplained poor responders during the pending ICSI cycle.
• Patients with abnormal findings at hysteroscopy.