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| ID | Type | Description | Link |
|---|---|---|---|
| 2014-A01169-38 | Other Identifier | IDRCB |
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Can brain MRI at entry of cocaine inpatient cessation attempt predict relapse during a three month follow-up ? Hypothesis : White matter losses in the prefrontal cortex are associated with relapse to cocaine use.
A multivariate model using MRI parameters, craving score, impulsivity score, and neuropsychological testing results will be tested to predict relapse or continuous abstinence three month after cocaine inpatient cessation attempt.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brain MRI imagery | Procedure | Brain MRI performed during the first week of inpatient cocaine cessation |
| Measure | Description | Time Frame |
|---|---|---|
| mean difference of fractional anisotropy of the prefrontal cortex (PFC) in patients abstinent from cocaine 3 months after inpatient detoxification compared to relapsers | at 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse | Differences in grey and white matter volumes : voxel-based morphometry (VBM) and in resting-state whole-brain activity default mode network (DMN) | at baseline |
| Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse |
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Inclusion Criteria:
Exclusion Criteria:
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cocaine dependent patient requiring inpatient cessation
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| Name | Affiliation | Role |
|---|---|---|
| Florence VORSPAN, MD, PhD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Psychiatrie, Hôpital Fernand Widal | Paris | 75010 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38761123 | Derived | Poireau M, Clergue-Duval V, Maillard A, Icick R, Azuar J, Smith P, Faurent M, Volle E, Delmaire C, Cabe J, Bloch V, Vorspan F. Predictors of abstinence maintenance after cocaine inpatient detoxification: A prospective study. Am J Addict. 2024 Sep;33(5):576-582. doi: 10.1111/ajad.13571. Epub 2024 May 18. |
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| ID | Term |
|---|---|
| D019970 | Cocaine-Related Disorders |
| D007175 | Impulsive Behavior |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D001519 | Behavior |
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Differences in scores of craving (visual scale and Obsessive compusilve craving scale (OCCS) questionnaire) and impulsivity (UPPS) |
| at baseline |
| Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse | Differences in performance at the stroop test and in mental flexibility during an implicit set shifting task | at baseline |
| Among abstinent patients who remain abstinent at three months only :Differences between baseline and 3 months measures of Diffusion Tensor Imagery (DTI), VBM and DMN | at 3 months |
| Among abstinent patients who remain abstinent at three months only: Differences in scores of craving (visual scale and OCCS questionnaire) and impulsivity (UPPS) | at 3 months |
| Among abstinent patients who remain abstinent at three months only: Differences in performance at the stroop test and in mental flexibility during an implicit set shifting task compared to baseline results | at 3 months |