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| Name | Class |
|---|---|
| Fundação de Amparo à Pesquisa do Estado de São Paulo | OTHER_GOV |
| Coordenação de Aperfeiçoamento de Pessoal de NÃvel Superior. | OTHER_GOV |
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Inflammatory markers have been analyzed in several diseases of unknown etiology, in the expectation of increasing therapeutic perspectives. This possibility arises from the different levels of tissue injury with low-grade chronic inflammation that have been observed in studies in which the markers were not evaluated traditionally, and today have influenced clinical management.
The investigators aimed, therefore, to evaluate the inflammatory markers in patients with AIS before and after aerobic and combined exercise training.
Inflammatory markers have not been evaluated in adolescent idiopathic scoliosis (AIS), but this deformity potentially involves various musculoskeletal structures permanently, which justifies the analysis. A low-grade chronic inflammation may be related to the lower capacity in exercise performance observed in this population, which must be stimulated to perform standardized physical activity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| combined group (treadmill and resisted) | Experimental | - 10 minutes of warming, aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate) and resisted training in equipment and free weights for 10 minutes with a set of 10 repetitions in quadriceps, triceps and biceps of the arms and legs (36 sessions) |
|
| aerobic group (treadmill) | Active Comparator | 10 minutes of warming, aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate) for 36 sessions |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| aerobic exercise | Other | aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate) |
|
| Measure | Description | Time Frame |
|---|---|---|
| interleukin 1 | Inflammatory Markers | change from baseline in interleukin 1 at 3 months |
| interleukin 6 | Inflammatory Markers | change from baseline in interleukin 6 at 3 months |
| interleukin 8 | Inflammatory Markers | change from baseline in interleukin 8 at 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| distance in six-minute walk test | analysis of distance | change from baseline in distance at 3 months |
| oxygen saturation in six-minute walk test | analysis of oxygen saturation at end of test |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Santa Casa of Sao Paulo Medical School | São Paulo | 01221-020 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31859153 | Derived | Xavier VB, Avanzi O, de Carvalho BDMC, Alves VLDS. Combined aerobic and resistance training improves respiratory and exercise outcomes more than aerobic training in adolescents with idiopathic scoliosis: a randomised trial. J Physiother. 2020 Jan;66(1):33-38. doi: 10.1016/j.jphys.2019.11.012. Epub 2019 Dec 16. |
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| ID | Term |
|---|---|
| D012600 | Scoliosis |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D013121 | Spinal Curvatures |
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D005080 | Exercise Test |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| combined exercise | Other | aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate); resisted training in equipment and free weights for 10 minutes with a set of 10 repetitions in quadriceps, triceps and biceps of the arms and legs |
|
| treadmill | Device |
|
| change from baseline in oxygen saturation at 3 months |
| systolic blood pressure in six-minute walk test | analysis of systolic blood pressure at end of test | change from baseline in systolic blood pressure at 3 months |
| diastolic blood pressure in six-minute walk test | analysis of diastolic blood pressure at end of test | change from baseline in diastolic blood pressure at 3 months |
| heart rate in six-minute walk test | analysis of heart rate at end of test | change from baseline in heart rate at 3 months |
| respiratory frequency in six-minute walk test | analysis of respiratory frequency at end of test | change from baseline in respiratory frequency at 3 months |
| Borg scale in six-minute walk test | analysis of Borg scale at end of test | change from baseline in Borg scale at 3 months |
| forced vital capacity (FVC) | analyzed in liters or % of predicted of lung capacity variation from baseline at 3 months | change from baseline at 3 months |
| maximal inspiratory pressure (MIP) | analysis of maximal inspiratory pressure variation (cmH2O) | change from baseline at 3 months |
| maximal expiratory pressure (MEP) | analysis of maximal expiratory pressure variation (cmH2O) | change from baseline at 3 months |
| peak expiratory flow | peak expiratory flow variation analysis in liters / minute (l/min) | change from baseline at 3 months |
| forced expiratory volume in the first second (FEV1) | analyzed in liters or % of predicted of lung volume variation from baseline at 3 months | change from baseline at 3 months |
| forced expiratory volume in the first second (FEV1) / forced vital capacity (FVC) | Analysis (%) of the relationship between FEV1 and FVC with variation from baseline at 3 months | change from baseline at 3 months |
| FORCED EXPIRATORY FRACTION (FEF25-75%) | analyzed in milliliters (ml) of lung volume variation from baseline at 3 months | change from baseline at 3 months |
| FORCED EXPIRATORY FRACTION (FEF25-75%) / forced vital capacity (FVC) | Analysis (%) of the relationship between FEV1 and FVC with variation from baseline at 3 months | change from baseline at 3 months |
| D001519 |
| Behavior |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D016552 | Ergometry |
| D008919 | Investigative Techniques |