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This research project is a study to immunology changes in critically ill patients with severe sepsis by using Endotoxin Activity Assay (EAA) combined with Polymyxin-B Hemoperfusion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High EAA and use Polymyxin-B Hemoperfusion | Experimental | EAA level > 0.6 or EAA = 0.6 and use Polymyxin-B Hemoperfusion |
|
| High EAA and not use Polymyxin-B Hemoperfusion | Experimental | EAA level > 0.6 or EAA = 0.6 and not use Polymyxin-B Hemoperfusion |
|
| Low EAA | Active Comparator | EAA level < 0.6 and not use Polymyxin-B Hemoperfusion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Polymyxin-B Hemoperfusion | Procedure | Endotoxin removal |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Functions of cell surface markers | CD11b expression on PMN and HLA-DR expression on monocyte | 3 days |
| Chemotaxis | Neutrophil function | 3 days |
| EAA level | Endotoxin level | 3 days |
| Measure | Description | Time Frame |
|---|---|---|
| Survival rate | 28 days | |
| Sequential Organ Failure Assessment (SOFA Score) | 28 days | |
| Acute Kidney Injury and Renal Replacement Therapy incidences |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sasipha Tachaboon | Bangkok | Pathumwan | 10330 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30769293 | Derived | Singhan W, Vadcharavivad S, Areepium N, Wittayalertpanya S, Chaijamorn W, Srisawat N. The effect of direct hemoperfusion with polymyxin B immobilized cartridge on meropenem in critically ill patients requiring renal support. J Crit Care. 2019 Jun;51:71-76. doi: 10.1016/j.jcrc.2019.02.007. Epub 2019 Feb 5. | |
| 30367647 | Derived |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| Standard treatment |
| Procedure |
|
| 28 days |
| ICU length of stay | 28 days |
| Mechanical ventilation free day | 28 days |
| Srisawat N, Tungsanga S, Lumlertgul N, Komaenthammasophon C, Peerapornratana S, Thamrongsat N, Tiranathanagul K, Praditpornsilpa K, Eiam-Ong S, Tungsanga K, Kellum JA. The effect of polymyxin B hemoperfusion on modulation of human leukocyte antigen DR in severe sepsis patients. Crit Care. 2018 Oct 26;22(1):279. doi: 10.1186/s13054-018-2077-y. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |