Brain Metabolism in Polycystic Ovary Syndrome

Brain Metabolism in Women With Polycystic Ovary Syndrome: a PET/MRI Study

The purpose of this study is to investigate whether higher insulin resistance in young women with Polycystic ovary syndrome (PCOS) is associated with reduced cerebral metabolic rate of glucose (CMRglu). Brain volumes using magnetic resonance imaging (MRI) and quantitative cerebral glucose uptake using dynamic positron emission tomography (PET) were obtained.

MRI and FDG PET scan for each participant were obtained within an average time frame of 3 weeks. Isulin resistance were assessed with the updated homeostasis model assessment (HOMA2-IR).

Inclusion Criteria:

• Diagnosis of PCOS
• Age ≤ 35 y
• BMI ≤ 35

Exclusion Criteria:

• Taking medications for diabetes or insulin-sensitizing drugs
• Drug addictions
• Psychiatric illness
• Smoking
• Overt evidence of heart, liver or renal disease