Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to investigate whether higher insulin resistance in young women with Polycystic ovary syndrome (PCOS) is associated with reduced cerebral metabolic rate of glucose (CMRglu). Brain volumes using magnetic resonance imaging (MRI) and quantitative cerebral glucose uptake using dynamic positron emission tomography (PET) were obtained.
MRI and FDG PET scan for each participant were obtained within an average time frame of 3 weeks. Isulin resistance were assessed with the updated homeostasis model assessment (HOMA2-IR).
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| POLYCYSTIC OVARY SYNDROME (PCOS) | FDG PET scan,T1-weight MRI and blood were obtained for each participant |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Global Brain Glucose PET Uptake | Global brain glucose uptake was quantified using FDG with dynamic positron emission tomography. | Single point in time (day 1) |
| Brain MR Volumes | T1-weighted brain MR images were obtained on a 1.5 Tesla scanner. Regional volumes were determined using FreeSurfer Suite 5.0 software. | Single point in time (day 2) |
| Insulin Resistance (HOMA2-IR) | The homeostasis model assessment computational method was used to estimate insulin resistance (HOMA2-IR) from fasting plasma glucose and insulin. The HOMA2-IR is the reciprocal of insulin sensitivity (%S), as a percentage of a normal reference population (normal young adult). A higher score indicates a lower insulin sensitivity. | Single point in time (day 1 during the FDG PET) |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Women with PCOS (n=7) were referred by physician specialist in endocrinology between March, 2010 and September, 2013. The diagnosis of PCOS was based on clinical examination using the Rotterdam criteria.
Not provided
Women with PCOS diagnosed during a clinical examination using the Rotterdam criteria were recruited.
Not provided
| ID | Title | Description |
|---|---|---|
| FG000 | POLYCYSTIC OVARY SYNDROME (PCOS) | Women with PCOS. FDG PET scan,T1-weight MRI and a blood sample for the evaluation of insulin resistance were obtained within an average time frame of 3 weeks. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | POLYCYSTIC OVARY SYNDROME (PCOS) | Women with PCOS diagnosed during a clinical examination using the Rotterdam criteria. PET and MRI exams: FDG PET scan and T1-weight MRI were obtained within an average time frame of 3 weeks. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Global Brain Glucose PET Uptake | Global brain glucose uptake was quantified using FDG with dynamic positron emission tomography. | Posted | Mean | Standard Deviation | umol/100 g/min | Single point in time (day 1) |
|
|
Not provided
Adverse Events were not monitored/assessed
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | POLYCYSTIC OVARY SYNDROME (PCOS) | Women with PCOS diagnosed during a clinical examination using the Rotterdam criteria. PET and MRI exams: FDG PET scan and T1-weight MRI were obtained within an average time frame of 3 weeks. |
Not provided
Not provided
Not provided
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Stephen Cunnane | USherbrooke | 1-819-780-2220 | 45670 | Stephen.Cunnane@USherbrooke.ca |
Not provided
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Blood plasma
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
|
| Primary | Brain MR Volumes | T1-weighted brain MR images were obtained on a 1.5 Tesla scanner. Regional volumes were determined using FreeSurfer Suite 5.0 software. | Posted | Mean | Standard Deviation | ml | Single point in time (day 2) |
|
|
|
| Primary | Insulin Resistance (HOMA2-IR) | The homeostasis model assessment computational method was used to estimate insulin resistance (HOMA2-IR) from fasting plasma glucose and insulin. The HOMA2-IR is the reciprocal of insulin sensitivity (%S), as a percentage of a normal reference population (normal young adult). A higher score indicates a lower insulin sensitivity. | Posted | Mean | Standard Deviation | HOMA2-IR score | Single point in time (day 1 during the FDG PET) |
|
|
|
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
Not provided
Not provided