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The purpose of this study is to explore the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.
Prospective studies have linked impaired cognitive control to increased cognitive vulnerability for future depression. Importantly, experimental studies indicate that cognitive control training can be used to reduce rumination and depressive symptomatology in MDD samples. Furthermore, studies exploring the potential of cognitive control training in at-risk undergraduate students indicate that cognitive control training has beneficial effects on rumination, an important vulnerability factor for depression. Provided that remitted depressed patients form a high-risk group for developing future depressive episodes, the current study will explore whether internet-delivered cognitive control training can be used to reduce vulnerability for future depression in remitted depressed patients. The investigators will explore effects on depressive symptomatology, (mal-)adaptive emotion regulation (directly following training and at 3 months follow-up), and indices of functioning (at 3 months follow-up).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cognitive control training | Experimental | internet-delivered, 2 weeks |
|
| low cognitive load training | Active Comparator | internet-delivered, 2 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive Control Training | Behavioral | 10 adaptive Paced Auditory Serial Addition Task (PASAT) sessions, 400 trials each |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in depressive rumination from baseline to the post-training assessment and follow-up (RRS) | Assessed using the Ruminative Response Scale (RRS) | baseline, 2 weeks, 3 months |
| Change in depressive symptomatology from baseline to the post-training assessment and follow-up (BDI-II) | Assessed using the Beck Depression Inventory (BDI-II) | baseline, 2 weeks, 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| (mal-)Adaptive cognitive emotion regulation (CERQ) | Assessed using the Cognitive Emotion Regulation Questionnaire (CERQ) | baseline, 2 weeks, 3 months |
| Quality of Life (QLDS) | Assessed using the Quality of Life in Depression Scale (QLDS) |
| Measure | Description | Time Frame |
|---|---|---|
| Behavioral measure for cognitive control ((non-adaptive) PASAT) | Assessed using the (non-adaptive) PASAT | baseline, 2 weeks, 3 months |
| Self-reported cognitive control (BRIEF-A) | Assessed using the Behaviour Rating Inventory of Executive Function Adult Version (BRIEF-A) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ernst Koster, PhD | University Ghent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ghent University | Ghent | Oost-Vlaanderen | 9000 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27362792 | Derived | Hoorelbeke K, Koster EHW. Internet-delivered cognitive control training as a preventive intervention for remitted depressed patients: Evidence from a double-blind randomized controlled trial study. J Consult Clin Psychol. 2017 Feb;85(2):135-146. doi: 10.1037/ccp0000128. Epub 2016 Jun 30. | |
| 26055122 | Derived |
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| Low Cognitive Load Training | Behavioral | 10 low cognitive load sessions, 400 trials each |
|
| baseline, 3 months |
| Disability (WHODAS 2.0) | Assessed using the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) | baseline, 3 months |
| Resilience (RS) | Assessed using the Resilience Scale (RS) | baseline, 3 months |
| Remission from depression (RDQ) | Assessed using the Remission of Depression Questionnaire (RDQ) | baseline, 3 months |
| baseline, 2 weeks, 3 months |
| Hoorelbeke K, Faelens L, Behiels J, Koster EH. Internet-delivered cognitive control training as a preventive intervention for remitted depressed patients: Protocol for a randomized controlled trial. BMC Psychiatry. 2015 Jun 9;15:125. doi: 10.1186/s12888-015-0511-0. |