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Using a pulse oximeter, we have developed an algorithm that estimates intracranial pressure (ICP) based on patients who have had traumatic brain injuries. Patients with hydrocephalus are typically treated with a shunt in order to reduce ICP. At times the shunt can malfunction. We believe that our algorithm will help identify when a hydrocephalus patient's shunt has malfunctioned.
A malfunctioning ventriculoperitoneal (VP) shunt will typically cause a rise in intracranial pressure, which can be difficult to identify without costly imaging. Novel, state-of-the art machine learning techniques can be leveraged to develop an algorithm that noninvasively estimates intracranial pressure. The resulting algorithm will accurately determine the presence or absence of ventriculoperitoneal shunt malfunction in patients with hydrocephalus.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| VP shunt functioning | No intervention, just a physiological category--patients with VP shunts that are functioning normally. |
| |
| VP shunt malfunctioning | No intervention, just a physiological category--patients with VP shunts that are malfunctioning. |
| |
| No known intracranial pathology | No intervention, just a physiological category--patients without VP shunts that have no known intracranial pathology. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pulse oximetry | Device | Pulse oximetry |
|
| Measure | Description | Time Frame |
|---|---|---|
| The presence or absence of ventriculoperitoneal shunt malfunction in patients with hydrocephalus | The algorithm development | baseline |
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Inclusion Criteria:
Exclusion Criteria:
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VP shunted patient, Normal intracranial pathology patient
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| Name | Affiliation | Role |
|---|---|---|
| Steve Moulton, MD | Children's Hospital Colorado | Principal Investigator |
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| ID | Term |
|---|---|
| D006849 | Hydrocephalus |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D010092 | Oximetry |
| ID | Term |
|---|---|
| D001784 | Blood Gas Analysis |
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
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| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D008919 | Investigative Techniques |