Comparison of a Plant Protein Diet to a Animal Protein Diet Emphasized in Type 2 Diabetics

Comparison of a High-protein, Carbohydrate-restricted Diet With a High Proportion of Leguminous Protein Compared to Animal Protein on Metabolic Control in Patients With Type 2 Diabetes, "LeguAN Study"

This 6-week parallel randomised prospective dietary intervention study with type 2 Diabetes investigates the nutrition influence of animal protein in comparison to plant protein on the glucose metabolism.

2x20 patients with Diabetes mellitus type 2 are randomise by a blind computer assist for an equal allocation in both groups (animal protein vs. plant protein). The food components for both groups are 40% carbohydrates, 30% fat and 30% protein. The carbohydrates are correspond with a high fiber content and a low blood sugar effectiveness of carbohydrates (glycemic index).

Inclusion Criteria:

• Diabetes mellitus, type 2
• HbA1c between 6-11%

Exclusion Criteria:

• Consumptive or high grade diseases
• Intake of metabolic influence a/o anticoagulent drugs (e.g. cortisone, ASS, antibiotics)
• Diabetes type 1
• Pregnancy
• Chronic disease of heart, kidney, liver
• High grade anaemia
• High grade infection disease
• Relevant change of body weight (+/- 5 kg) since 8 weeks before begin of study Intervention
• Missing data about primary outcome measures (hyperinsulinaemic euglycaemic clamp, mealtime test, data about dietary intake from food diaries or food protocols)
• Significant deviation from dietary targets during the monitored 6 weeks isoenergetic period
• Allergies including food allergies