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The aim of this study is to identify the effect of Polygoni Multiflori Radix complex extract on memory improvement using Rey-Kim scale for healthy people.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Polygoni Multiflori Radix complex | Experimental | Participants randomized to the experimental group will take one capsule of Polygoni Multiflori Radix complex extract (250mg) twice a day, 30 minutes after breakfast and dinner for 4 weeks. |
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| Starch | Placebo Comparator | Participants randomized to the placebo group will take one capsule of placebo(250mg) twice a day, 30 minutes after breakfast and dinner for 4 weeks. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Polygoni Multiflori Radix complex extract | Dietary Supplement | Intervention is manufactured by Chun-Ho food |
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| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline on Memory Quotient score at 2 weeks and 4 weeks | baseline, at 2 weeks after taking experimental or placebo dietary supplement, at 4 weeks after taking supplement |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in Memory registration at 2 weeks and 4 weeks | Rey-Kim scale is a tool to assess the short-term memory. It is composed of AVLT and CFT. # AVLT After tester speaks each 15 word, subjects are asked to tell all words immediately as memory serves. This process is repeated 5 times (Each process is called AVLT process 1-5 according to priority). After 20 minutes interval, subjects are also asked to tell all words they can remember (AVLT process 6). Right after that, subjects should select the words they heard among 35 words (AVLT process 7). Memory registration is calculated by converting score difference into a percentage between AVLT process 1 and 5 mentioned above. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| In Lee, Doctor | Pusan National University Korean Medicine Hospital | Study Chair |
| Hye-lim Park, Master | Pusan National University Korean Medicine Hospital | Principal Investigator |
| Eunhye Jeong, bachelor | National Clinical Research Center for Korean Medicine Pusan National University Korean Medicine Hospital | Principal Investigator |
| Hana Lee, bachelor | National Clinical Research Center for Korean Medicine Pusan National University Korean Medicine Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pusan National University Korean Medicine Hospital | Yangsan | Gyeongsangnam-do | 626-770 | South Korea |
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| Placebo | Dietary Supplement | The placebo is filled with starch, so does not contain the active ingredient. |
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| baseline, at 2 weeks after taking experimental or placebo dietary supplement, at 4 weeks after taking supplement |
| Change from baseline in Memory retention at 2 weeks and 4 weeks | # AVLT After tester speaks each 15 word, subjects are asked to tell all words immediately as memory serves. This process is repeated 5 times (Each process is called AVLT process 1-5 according to priority). After 20 minutes interval, subjects are also asked to tell all words they can remember (AVLT process 6). Right after that, subjects should select the words they heard among 35 words (AVLT process 7). Memory retention is calculated by converting score difference into a percentage between AVLT process 5 and 6 mentioned above. | baseline, at 2 weeks after taking experimental or placebo dietary supplement, at 4 weeks after taking supplement |
| Change from baseline in Retrieval efficiency at 2 weeks and 4 weeks | # AVLT After tester speaks each 15 word, subjects are asked to tell all words immediately as memory serves. This process is repeated 5 times (Each process is called AVLT process 1-5 according to priority). After 20 minutes interval, subjects are also asked to tell all words they can remember (AVLT process 6). Right after that, subjects should select the words they heard among 35 words (AVLT process 7). Retrieval efficiency is calculated by converting score difference into a percentage between AVLT process 6 and 7 mentioned above. | baseline, at 2 weeks after taking experimental or placebo dietary supplement, at 4 weeks after taking supplement |
| Change from baseline in Copy-recall difference index at 2 weeks and 4 weeks | Rey-Kim scale is a tool to assess the short-term memory. It is composed of AVLT and CFT. # CFT After tester shows subjects very complicated figure, subjects are asked to copy it (CFT process 1). Right after that, subjects should draw the figure as memory serves (CFT process 2). After 20 minutes interval, subjects are also asked to select the part of figure they copy among various figures (CFT process 3). Copy-recall difference index is calculated by converting score difference into a percentage between CFT process 1 and 2 mentioned above. | baseline, at 2 weeks after taking experimental or placebo dietary supplement, at 4 weeks after taking supplement |