This prospective clinical study will evaluate the safety and efficacy of the Cook® Antimicrobial Hernia Repair Device containing an antimicrobial to reinforce soft tissue during ventral or incisional hernia repair in clean-contaminated, contaminated, and dirty-infected (i.e., Class II, Class III, and Class IV) surgical fields. Up to 30 patients will be treated with the Cook® Antimicrobial Hernia Repair Device and patients will be followed for 12 months.

Inclusion Criteria:

• Patient presents with a ventral or incisional hernia that is to be surgically corrected using open repair technique

Exclusion Criteria:

• Body Mass Index (BMI) < 25.
• Body weight < 45 kg
• Glycosylated Hemoglobin (Hgb A1c) > 10%
• Albumin < 2.5 g/dL or pre-albumin < 5.0 mg/dL
• Renal insufficiency, as determined by an estimated glomerular filtration rate (GFR) < 60 mL/min/1.73 m2
• Known allergies to study device components
• Other relevant exclusion criteria apply