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Prospoctive cohort of high-dose cyclophosphamide exposed patients. With active estandardize screening of hyponatremia development in the follow up period.
Primary objectives
Study design. Observational prospective cohort study of Patients after infusion of high-dose cyclophosphamide. Follow up period will be from cyclophosphamide infusion until one month after hospital discharge.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High-dose Cyclophosphamide | Patients requiring infusion of high-dose cyclophosphamide in the period 2015-2017 will be included. After informed consent, patients will de follow up from the infusion of cyclophosphamide to 30 days after hospital discharge. |
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| Measure | Description | Time Frame |
|---|---|---|
| Hyponatremia | Hyponatremia, measured as any value sodium after infusion and defined as positive if sodium less than 135 mEq / l (Yes / No, dichotomous categorical variable). For the incidence of hyponatremia is only included in the calculation hionatremia patients with normal sodium before infusion. | Between 6 and 8 hours after the infusion of cyclophosphamide is performed. |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients (Over 18 years) admitted for high-dose cyclophosphamide.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fernando Warley, MD | Contact | +54 9 11 61541958 | fernando.warley@hospitalitaliano.org.ar | |
| Belen Bonella, MD | Contact | +54 9 11 21620279 | maria.bonella@hospitalitaliano.org.ar |
| Name | Affiliation | Role |
|---|---|---|
| Fernando Warley, MD | Hospital Italiano de Buenos Aires | Principal Investigator |
| Belen Bonella, MD | Hospital Italiano de Buenos Aires | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Italiano de Buenos Aires, Peron 4190 | Buenos Aires | Buenos Aires F.D. | C1199ABB | Argentina |
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| ID | Term |
|---|---|
| D007010 | Hyponatremia |
| ID | Term |
|---|---|
| D014883 | Water-Electrolyte Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Victoria Otero, MD |
| Hospital Italiano de Buenos Aires |
| Principal Investigator |
| Bruno L Ferreyro, MD | Hospital Italiano de Buenos Aires | Principal Investigator |