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| Name | Class |
|---|---|
| Regionshospitalet Hammel Neurocenter | OTHER |
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Investigates computer based cognitive rehabilitation and training using the N-back task with a Visual Search task as an active control. The overall purpose is to provide (further) evidence about the efficacy (or lack of efficacy) of the N-back task and to find points of convergence and divergence between patients with acquired brain injury and non-impaired subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient N-back | Experimental | Patients training the N-back task |
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| Patient Visual Search | Active Comparator | Patients training the Visual-Search task |
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| Non-impaired N-back | Experimental | Non-impaired training the N-back task |
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| Non-impaired Visual Search | Active Comparator | Non-impaired training the Visual-Search task |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| N-back | Behavioral | The N-back task required patients to monitor a continuous sequence of stimuli (in this experiment audio and visual stimuli). Press a button if the current stimulus is the same as that shown N back in the sequence. N increases if performance is good and decreases if performance is poor. Subjects train for 20 days, 12 blocks a day, 20+N trials per block. That is 240 blocks in total. A minimum of 10 blocks per day counts as a successfully trained day. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline Raven's advanced progressive matrices at the end of training | within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline WAIS-III Working Memory Index at the end of training | within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline. | |
| Change from baseline WAIS-III Processing Speed Index at the end of training |
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Inclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jonas Lindeløv, M.Sc. | Hammel Neurocenter | Principal Investigator |
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| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
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| Visual Search | Behavioral | The Visual Search task consists of a NxN array of shapes. Press the button if a certain target stimulus is present in this array. N increases if performance is good and decreases if performance is poor. Subjects train for 20 days, 12 blocks a day, 20+N trials per block. That is 240 blocks in total. A minimum of 10 blocks per day counts as a successfully trained day. |
|
| within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline. |
| Change from baseline Operation Span at the end of training | within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline. |
| Change from baseline Stroop color-text interference at the end of training | within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline. |
| Change from baseline AMPS at the end of training | within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline. |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |