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A national, multicenter, randomized, transverse clinical trial, estimating the existence of phonological deficits in children with NF1 children compared with control children without NF1 with the same reading level.
To determine the phonological and visio -spatial performances at the NF1 children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children NF1 | Experimental | Children diagnosed with NF1 according the NIH criteria Neuropsychological assessments |
|
| Control group | Placebo Comparator | Control group children without NF1 with the same reading level Neuropsychological assessments |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuropsychological assessments | Other | Neuropsychological assessments: Intelligence Quotient (WISC-IV) Reading tests (reading accuracy, reading speed, reading comprehension and strategy): Alouette test, Lobrot test, Odedys test. Visio-spatial skill (JLO, Thurston, Corsi tests) Attention (CPT 2, CBCL) Receptive oral language (EVIP) |
| Measure | Description | Time Frame |
|---|---|---|
| Phonological deficits evaluated by the metaphonological capabilities including a subtraction test and phonemic Acronym test and memory capacity with phonological phonological memory test. | Evaluate whether there is a specificity of phonological deficits in children with NF1 compared with a population of children with the same age and same reading level, taking into account the intellectual level. | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Visual-perceptual performance established from three tests: Test of Identical Forms (Thurstone), Judgment Test of orientation Lines (Benton) and global and partial deferral Tasks (S Valdois). | Studying the correlations between phonological deficits and visio-spatial and literacy skills. | 24 hours |
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Inclusion Criteria:
Age included between 8 and 12 years
Child presenting a type 1 neurofibromatosis according to 2 criteria in the following criteria list :
Membership in a national insurance
Consent of the child and the parents
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yves CHAIX, Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital femme-mére-enfant, Hospices civils de lyon | Lyon | 69677 | France | |||
| Hôpital Gui de Chauliac |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33507832 | Derived | Biotteau M, Tournay E, Baudou E, Destarac S, Iannuzzi S, Faure-Marie N, Castelnau P, Schweitzer E, Rodriguez D, Kemlin I, Dorison N, Rivier F, Carneiro M, Preclaire E, Barbarot S, Lauwers-Cances V, Chaix Y. Reading Comprehension Impairment in Children With Neurofibromatosis Type 1 (NF1): The Need of Multimodal Assessment of Attention. J Child Neurol. 2021 Jul;36(8):625-634. doi: 10.1177/0883073820981270. Epub 2021 Jan 28. |
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| ID | Term |
|---|---|
| D009456 | Neurofibromatosis 1 |
| D004410 | Dyslexia |
| ID | Term |
|---|---|
| D017253 | Neurofibromatoses |
| D009455 | Neurofibroma |
| D018317 | Nerve Sheath Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
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|
| Montpellier |
| 34295 |
| France |
| CHU Hôtel-Dieu, Clinic of Dermatology | Nantes | 44903 | France |
| AP-HP Hopital Armand Trousseau | Paris | 75012 | France |
| Hôpital des Enfants | Toulouse | 31073 | France |
| Hopital Gatien de Clocheville | Tours | 37000 | France |
| D009370 |
| Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009386 | Neoplastic Syndromes, Hereditary |
| D020752 | Neurocutaneous Syndromes |
| D009422 | Nervous System Diseases |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D019636 | Neurodegenerative Diseases |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D000067559 | Specific Learning Disorder |
| D007859 | Learning Disabilities |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |