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Pending additional funding
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The investigators are studying the utility of intra-operative magnetic resonance imaging (iMRI) during transsphenoidal pituitary surgery for large macroadenomas by randomizing patients to either an intra-operative MRI after resection, or no intra-operative MRI. The investigators will then count the number of gross total resection in each group of patients and also the complications related to surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No intra-operative MRI | Placebo Comparator | Patients undergo transsphenoidal surgery without an intra-operative MRI. |
|
| intra-operative MRI | Experimental | Patients undergo transspheonidal surgery followed by intra-operative MRI. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intra-operative MRI | Other | Intra-operative magnetic resonance imaging under general anesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of gross total or maximal resection | Determine whether use of iMRI in transsphenoidal pituitary surgery for pituitary macroadenomas significantly increases the rate of maximal resection | 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Operative time | Length of operation | intraoperative |
| Frequency of post-operative CSF leak | Frequency of post-operative Cerebrospinal Fluid (CSF) leak |
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Inclusion Criteria:
Adults 18-90
Capable of giving informed consent
Elect for transsphenoidal surgery
Has pre-operative MRI demonstrating pituitary tumor that is:
No contraindications for MRI.
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03765 | United States |
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| Transsphenoidal resection of pituitary macroadenoma | Procedure | Routine transsphenoidal resection of pituitary macro adenomas |
|
| 30 days post surgery |
| Rate of Readmission | Frequency of readmission | 30 days post surgery |
| Length of anesthesia time | Length of time participant is under anesthesia | intraoperative |
| Rate of post-operative endocrinopathies | Rate of post-operative endocrinopathies | 30 days post surgery |