Ragweed-SPIRE Follow-On Study

An Observational Follow-On Field Study to Evaluate the Continued Efficacy and Safety of Ragweed-SPIRE Treatment in Ragweed Allergic Subjects Approximately One Year After the Completion of Treatment

The purpose of this study is to determine the efficacy of Ragweed-SPIRE 12 months after the initial dose.

Inclusion Criteria:

° Previously randomised into and completed at least 6 of 8 treatment visits in Study TR006

Exclusion Criteria:

• Subject or Investigator have been informed of treatment received in Study TR006
• Subjects with significant allergy to animal dander
• Any allergen immunotherapy since completing Study TR006 or use of prohibited therapies
• History of recurrent acute sinusitis or chronic sinusitis
• Received treatment with an investigational drug within 4 weeks of Screening
• Unable to understand study requirements or unable to communicate clearly with Investigator