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Influenza is a major cause of morbidity and mortality. The investigators first goal is to evaluate soluble HLA-G5 isoform serum level as a potential marker of greater risk of death from Influenza respiratory illness in adult and pediatric patients hospitalized in reanimation. Secondly, the investigators collected respiratory samples in order to study the transcriptomic profiles of influenza-infected patients with severe symptoms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| influenza cohort | Other | Influenza is a major cause of morbidity and mortality. The investigators' first goal is to evaluate soluble HLA-G5 isoform serum level as a potential marker of greater risk of death from Influenza respiratory illness in adult and pediatric patients hospitalized in reanimation. 1 control group of 30 patients (ancillary study) will be constitued to have reference values of the HLA-G5 marker. Secondly, the investigators collected respiratory samples in order to study the transcriptomic profiles of influenza-infected patients with severe symptoms. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| influenza cohort | Other | Influenza is a major cause of morbidity and mortality. The investigators' first goal is to evaluate soluble HLA-G5 isoform serum level as a potential marker of greater risk of death from Influenza respiratory illness in adult and pediatric patients hospitalized in reanimation. Secondly, the investigators collected respiratory samples in order to study the transcriptomic profiles of influenza-infected patients with severe symptoms. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in ratio of the partial pressure of oxygen in arterial blood (PaO2) to the inspired oxygen fraction (FiO2), from admission at 7 days post-admission | decreased arterial PaO2/FiO2 ratio ≤ 100 mmHg (≤ 13.3 kPa) | The first, third, fifth and seventh day of hospitalization in reanimation |
| Measure | Description | Time Frame |
|---|---|---|
| All cause mortality | 90 days after hospitalization | |
| Extracorporeal membrane oxygenation requirement | 90 days after hospitalization | |
| SOFA score (Adult) PELOD (Pediatric) |
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Inclusion Criteria:
For ancillary group :
Exclusion Criteria:
For ancillary group :
Presence of immunodepression defined by:
Infection in progress (fever)
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Sebastien CASALEGNO, MD/PhD | HOSPICES CIVILS DE LYON, Virology Department | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de Biologie et de Pathologie Nord | Lyon | Auvergne-Rhône-Alpes | 69500 | France | ||
| Hôpital Femme Mère Enfant |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36112363 | Result | Zhang Q, Pizzorno A, Miorin L, Bastard P, Gervais A, Le Voyer T, Bizien L, Manry J, Rosain J, Philippot Q, Goavec K, Padey B, Cupic A, Laurent E, Saker K, Vanker M, Sarekannu K; COVID Human Genetic Effort; Etablissement Francais du Sang Study Group; Constances Cohort; 3C-Dijon Study; Cerba HealthCare Group; Lyon Antigrippe Working Group; REIPI INF Working Group; Garcia-Salum T, Ferres M, Le Corre N, Sanchez-Cespedes J, Balsera-Manzanero M, Carratala J, Retamar-Gentil P, Abelenda-Alonso G, Valiente A, Tiberghien P, Zins M, Debette S, Meyts I, Haerynck F, Castagnoli R, Notarangelo LD, Gonzalez-Granado LI, Dominguez-Pinilla N, Andreakos E, Triantafyllia V, Rodriguez-Gallego C, Sole-Violan J, Ruiz-Hernandez JJ, Rodriguez de Castro F, Ferreres J, Briones M, Wauters J, Vanderbeke L, Feys S, Kuo CY, Lei WT, Ku CL, Tal G, Etzioni A, Hanna S, Fournet T, Casalegno JS, Queromes G, Argaud L, Javouhey E, Rosa-Calatrava M, Cordero E, Aydillo T, Medina RA, Kisand K, Puel A, Jouanguy E, Abel L, Cobat A, Trouillet-Assant S, Garcia-Sastre A, Casanova JL. Autoantibodies against type I IFNs in patients with critical influenza pneumonia. J Exp Med. 2022 Nov 7;219(11):e20220514. doi: 10.1084/jem.20220514. Epub 2022 Sep 16. |
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| ID | Term |
|---|---|
| D007251 | Influenza, Human |
| D012141 | Respiratory Tract Infections |
| ID | Term |
|---|---|
| D007239 | Infections |
| D009976 | Orthomyxoviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
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|
Elevated Score is considered as an evidence of clinical gravity |
| The first, third, fifth and seventh day of hospitalization in reanimation |
| Bron |
| France |
| CHU service réanimation adulte | Clermont-Ferrand | France |
| CHU service réanimation pédiatrique | Clermont-Ferrand | France |
| CHU service réanimation adulte | Dijon | France |
| CHU service réanimation pédiatrique | Dijon | France |
| CHU service réanimation adulte | Grenoble | France |
| CHU service réanimation pédiatrique | Grenoble | France |
| Centre de Biologie et Pathologie Est | Lyon | France |
| Hôpital de la Croix Rousse-service réanimation adulte chirurgicale | Lyon | France |
| Hôpital de la Croix Rousse-service réanimation adulte médicale | Lyon | France |
| Hôpital Edouard Herriot | Lyon | France |
| Centre Hospitalier Lyon Sud | Pierre-Bénite | France |
| CHU Service de Réanimation Adulte | Saint-Etienne | France |
| CHU Service de Réanimation Pédiatrique | Saint-Etienne | France |
| D012140 |
| Respiratory Tract Diseases |