A Clinical Trial to Assess the Potential of LEO 130852A Gel to Reduce Steroid Induced Skin Atrophy on Healthy Skin

A Prospective, Randomised, Investigator-Blinded, Vehicle-Controlled, Phase I Clinical Trial With Intra-Individual Comparison of Treatments to Assess the Potential of LEO 130852A Gel to Reduce Steroid Induced Skin Atrophy on Healthy Skin

The purpose of this study is to assess the effect of LEO 130852A gel 1% in maintaining skin thickness in healthy skin treated with steroid.

Inclusion Criteria:

• Healthy male volunteers, 25 to 50 years old inclusive
• Healthy skin on volar arms with a hairless area sufficient for measurements

Exclusion Criteria:

• Clinical skin atrophy, telangiectasia or striae on volar arms
• Presence of any skin condition or colouration that would interfere with test sites or the response or assessment
• Fitzpatrick skin type IV - VI
• History or current evidence of infection, eczema or other relevant skin disease