Effect of a High Density Formula on Growth and Safety in Congenital Heart Disease Infants

Effect of a High Density Formula on Growth and Safety in Early Postoperative Infants With Congenital Heart Disease Duration of Cardiac Intensive Care Unit（CCU）Stay: a Randomized Clinical Trial

The purpose of this study is to explore the effects of high density formula in early postoperative infants with congenital heart disease and to assess its safety.

The number of infants born with CHD increases every year and most CHD infants are suffered with malnutrition.Recent studies have shown that increasing energy intake in CHD infants can improve their nutrition status.But there are no high qualified evidences supporting that high density formula can promote infants' nutrition status and ensure its safety. The hypothesis of the current study is that high density formula intake can increase infants'weight and it's safe.

The current study adopts randomized,controlled intervention trial, gives high density formula(Infatrini,100kcal/100ml)to CHD infants in intervention group and normal density formula（Neocate,67kcal/100ml）in control group. Intervention begins when infants start enteral nutrition after operation and continues for 7days.

Inclusion Criteria:

1. diagnosis of congenital heart disease from symptoms, signs, ultrasonic and imaging examination
2. aged from 1 day to 12 months
3. accept extracorporeal circulation open-heart surgery
4. family members voluntarily participate in this study

Exclusion Criteria:

1. patients have other diseases which cause nutrition disorders, such as gastrointestinal malformation, preoperative gastroesophageal reflux, genetic diseases related to the growth restriction
2. accept total parenteral nutrition
3. predicted the length of CCU stay is less than five days
4. patients have abdominal distention, diarrhea, vomiting