Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Recently, positron emission tomography(PET) using 18F-Sodium fluoride (NaF) showed promising results for detecting vulnerable plaques in some pilot studies.
In this study, the investigators will evaluate the diagnostic accuracy of 18F-NaF PET for non-invasively detecting vulnerable plaque, diagnosed by optical coherence tomography (OCT).
It has been well known that mechanism of acute coronary syndrome is plaque rupture and occlusion of coronary artery by this plaque rupture. Until now, evaluation of vulnerable plaque have been mainly performed with invasive imaging modalities such as optical coherence tomography or intravascular ultrasound.
Recently, positron emission tomography(PET) using 18F-Sodium fluoride (NaF) showed promising results for detecting vulnerable plaques in some pilot studies.
In this study, we will evaluate the diagnostic accuracy of 18F-NaF PET for non-invasively detecting vulnerable plaque, diagnosed by optical coherence tomography (OCT).
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vulnerable plaque in optical coherence tomogrpahy | OCT-derived vulnerable plaque is defined as composite of thin-cap fibrous atheroma (cap thickness in optical coherence tomography < 60um), prominent macrophage, or prominent microvessels. | ||
| Non-vulnerable plaque in Optical coherence tomogrpahy | OCT-derived vulnerable plaque is defined as composite of thin-cap fibrous atheroma (cap thickness in optical coherence tomography < 60um), prominent macrophage, or prominent microvessels. OCT-derived non-vulnerable plaque is defined as a plaque without any of the findings |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Difference of tissue background ratio measured by 18F-NaF PET between Vulnerable and non-vulnerable plaque | Difference of tissue background ratio measured by 18F-NaF PET between Vulnerable and non-vulnerable plaque | up to 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Differencce of Maximum SUV value between Vulnerable and non-vulnerable plaque | Tissue-to-background ratios were calculated for each participant by dividing the maximal SUV measured in aortic valves by the mean SUV of blood in inferior vena cava | up to 1 week |
| Number of participants demonstrating at least 1 low-attenuation coronary atherosclerotic plaque |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Patients with angina pectoris
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bon-Kwon Koo, MD, PhD | Contact | 82-2-2072-2062 | bkkoo@snu.ac.kr | |
| Joo Myung Lee, MD, MPH | Contact | 82-2-2072-2062 | drone80@hanmail.net |
| Name | Affiliation | Role |
|---|---|---|
| Bon-Kwon Bon-Kwon, MD, PhD | Seoul National University Hospital | Principal Investigator |
| Paeng Jin Cheol, MD, PhD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Recruiting | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29133478 | Derived | Lee JM, Bang JI, Koo BK, Hwang D, Park J, Zhang J, Yaliang T, Suh M, Paeng JC, Shiono Y, Kubo T, Akasaka T. Clinical Relevance of 18F-Sodium Fluoride Positron-Emission Tomography in Noninvasive Identification of High-Risk Plaque in Patients With Coronary Artery Disease. Circ Cardiovasc Imaging. 2017 Nov;10(11):e006704. doi: 10.1161/CIRCIMAGING.117.006704. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Number of participants demonstrating at least 1 low-attenuation coronary atherosclerotic plaque |
| up to 1 week |
| Cardiac death and all-cause mortality | Between High-TBR and Low-TBR Plaque | 1 year |
| Non-fatal target vessel myocardial infarction | Between High-TBR and Low-TBR Plaque | 1 year |
| Target vessel revascularization | Between High-TBR and Low-TBR Plaque | 1 year |
| Target vessel restenosis | Between High-TBR and Low-TBR Plaque | 1 year |