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Chronic heart failure (CHF) is a clinical syndrome presented with central, cardiac deterioration as well as peripheral vascular and muscular abnormalities, resulting finally to reduced exercise tolerance, quality of life and mortality rates. Exercise training is a major component of rehabilitation / secondary prevention interventions, inducing significant beneficial changes in mechanisms of pathophysiology, exercise tolerance, functional capacity and quality of life, while a positive impact on hospitalization and mortality reduction should not be also excluded. There has been growing interest in the characteristics and modalities of exercise training able to induce optimal benefits. High intensity and interval mode have been shown to induce greater benefits than moderate intensity and continuous mode regimes. Additionally, there has been sound rationale for the inclusion of strength training, which has been also shown able to yield benefits in terms of exercise capacity and quality of life. However, there haven't been much data on the so called combined regimes, which include both aerobic exercise and strength training. This study aims at investigating the effects of combined high-intensity interval and strength training compared to high-intensity interval exercise alone in CHF.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Interval group | Active Comparator | high-intensity interval exercise training |
|
| Combined group | Active Comparator | combined exercise training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-intensity interval exercise training | Other | High-intensity interval exercise training [4 reps * (4 min at 80% VO2peak + 3 min at 50% VO2peak)] |
|
| Measure | Description | Time Frame |
|---|---|---|
| aerobic exercise capacity (assessed by cardiopulmonary exercise testing) | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| strength exercise capacity (assessed by 1-repetition maximum test) | 3 months | |
| quality of life (assessed by MLWHF questionnaire) | 3 months | |
| quadriceps local adaptations (assessed by muscle biopsies) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Serafim Nanas, MD, Prof. | Cardiopulmonary Exercise Testing & Rehabilitation Laboratory, 1st Critical Care Dpt, School of Medicine, University of Athens, Greece | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiopulmonary Exercise Testing & Rehabilitation Laboratory, 1st Critical Care Dpt, School of Medicine, University of Athens | Athens | 10675 | Greece |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39077398 | Derived | Tryfonos A, Tzanis G, Karatzanos Epsilon, Koutsilieris M, Nanas S, Philippou A. Inflammation- and Tissue Remodeling-Related Gene Responses in Skeletal Muscle of Heart Failure Patients Following High-Intensity Interval Training. Rev Cardiovasc Med. 2023 Feb 6;24(2):46. doi: 10.31083/j.rcm2402046. eCollection 2023 Feb. | |
| 39076879 | Derived |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Combined exercise training | Other | High intensity [2 reps * (4 min at 80% VO2peak + 3 min at 50% VO2peak)] and strength exercise training (2-4 sets, 10-12 reps, 60-65% 1RM, for quadriceps and hamstrings, 14 min in total) |
|
| 3 months |
| quadriceps cross sectional area (assessed by CT) | 3 months |
| Alshamari M, Kourek C, Sanoudou D, Delis D, Dimopoulos S, Rovina N, Nanas S, Karatzanos E, Philippou A. Does the Addition of Strength Training to a High-Intensity Interval Training Program Benefit More the Patients with Chronic Heart Failure. Rev Cardiovasc Med. 2023 Jan 16;24(1):29. doi: 10.31083/j.rcm2401029. eCollection 2023 Jan. |
| 34440684 | Derived | Tryfonos A, Tzanis G, Pitsolis T, Karatzanos E, Koutsilieris M, Nanas S, Philippou A. Exercise Training Enhances Angiogenesis-Related Gene Responses in Skeletal Muscle of Patients with Chronic Heart Failure. Cells. 2021 Jul 28;10(8):1915. doi: 10.3390/cells10081915. |