The Efficacy and Tolerability of Modafinil for Fatigue and Daytime Sleepiness in Cancer Patients: Preliminary Study

The Efficacy and Tolerability of Modafinil for Fatigue and Daytime Sleepiness in Cancer Patients: Preliminary Study

Open-pilot study for the efficacy and tolerability of modafinil on the fatigue and somnolence in cancer-patients.

This is an open-pilot study for the efficacy and tolerability of modafinil on the fatigue and somnolence in cancer-patients. Patients with moderate to severe cancer-related fatigue will be treated with modafinil for 4 weeks and psychological tests including self-questionnaire, cognitive test, sleep-wake cycle, quantitative electroencephalogram(QEEG) will be applied pre- and post-treatment.

Inclusion Criteria:

• solid cancer patient
• age of 20-65 years old
• subjects who scored =4 or >4 on the Brief Fatigue Inventory
• subjects with informed consent

Exclusion Criteria:

• metastatic cancer(stage IV)
• with psychotic symptoms such as delusion and hallucination or with suicidal risk
• with delirium or dementia
• current medication of cognitive enhancer or psychostimulant uncontrolled medical illness
• current medications that are contraindicated or not recommended for co-administration with modafinil