Biological Changes in the Adipose Tissue Among Pregnant Women With Diabetes

Biological Changes in the Adipose Tissue (RNA Profile) Among Pregnant Women With Diabetes

The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section. Healthy pregnant women will serve as a control group.

The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study:

1. fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section.
2. Bloods will be analyzed for insulin, c-peptide, glucose and fat profile
3. Placenta and fat tissue will be analyzed for miRNA and total RNA
4. Clinical and anthropometric measurements will be taken from the mother
5. Placenta status will be taken

Inclusion Criteria:

• age 18-45
• pregnant
• signed consent form
• going through an elective C-section
• Diabetic
• reference group: healthy women with no background illness

Exclusion Criteria:

• <18 or >45
• chronic illness that may effect the outcome
• polypharmacy