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Structural differences of supraglottic airway devices could influence the different compressive forces in the oropharyngeal cavities, and require different depth of anesthesia. The addition of remifentanil during propofol anesthesia facilitates the insertion of laryngeal mask airway (LMA) with minimal adverse hemodynamic disturbances. This study was designed to determine the effect-site concentration of remifentanil in 50% of patients (EC50) and 95% of patients (EC95) for successful i- gel insertion, and compare those for LMA insertion during propofol target-controlled infusion (TCI).
Anesthesia was induced with propofol TCI at the effect-site concentration of 5 μg/ml, and the predetermined effect-site concentration of remifentanil was started simultaneously. The remifentanil concentration was determined using modified Dixon's up-and-down method (initial concentration: 3.0 ng/ml, step size: 0.5 ng/ml). Five minutes later, i- gel or LMA insertion was attempted. The response of the patients to the insertion of LMA was classified as either 'movement' or 'no movement'.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| i-gel | Experimental | I-gel insertion was attempted during propofol and remifentanil anesthesia . |
|
| laryngeal mask airway | Active Comparator | LMA insertion was attempted during propofol and remifentanil anesthesia . |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| remifentanil | Drug | The predetermined effect-site concentration of remifentanil was started using modified Dixon's up-and-down method |
|
| Measure | Description | Time Frame |
|---|---|---|
| successful insertion of i-gel and LMA | from 5 min after anesthetic induction to 1min after device insertion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jong Yeop Kim, MD | Ajou University School of Medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ajou University hospital | Suwon | 443-721 | South Korea |
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| ID | Term |
|---|---|
| D000077208 | Remifentanil |
| D017214 | Laryngeal Masks |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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|
| i-gel | Device | I-gel insertion was inserted 5 min after anesthesia induction |
|
| laryngeal mask airway | Device | laryngeal mask airway insertion was inserted 5 min after anesthesia induction |
|
| propofol | Drug | Anesthesia was induced with propofol target-controlled infusion at the effect-site concentration of 5 μg/ml |
|
|
| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D007442 | Intubation, Intratracheal |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D007440 | Intubation |
| D008919 | Investigative Techniques |
| D008397 | Masks |
| D011482 | Protective Devices |
| D004864 | Equipment and Supplies |
| D000067393 | Personal Protective Equipment |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |