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The current etiological pathological model of anorexia nervosa is poly-factorial involving individual genetic and psychological factors, in close interaction with environmental, family and socio-cultural factors.
Among these factors, this study focuses on the central coherence process (cognitive ability to integrate complex information into a comprehensive meaning), in the active phase of the disease. Therefore, patients followed in the addiction service of the Nantes University Hospital will perform neuropsychological tests assessing executive functions involved in the process of central coherence.
Impairment of central coherence process could act as a maintenance factor of the disease, particularly in connection with body dysmorphic disorder. The therapeutic perspectives acting on the central coherence process like cognitive remediation deserve to deepen knowledge on the cognitive profile of patients with anorexia nervosa.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | Other | patients followed in the addiction service of the University Hospital of Nantes (consultations and / or hospitalizations) for restrictive anorexia nervosa |
|
| Healthy volunteers | Other | control subjects matched for age and sex with the patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment | Behavioral | The content of the assessment will be the same for all subjects and will consist of a part of cognitive assessment (National Reading Test, Rey Osterreich Complex Figure, Hayling Sentence Completion Task, verbal memory, digit sequencing, token motor task, verbal fluencies, symbol coding, tower of London) and self-assessment (Mini International Neuropsychiatric Interview, Beck Depression Inventory, State Trait Anxiety Inventory, Wender Utah Rating Scale, Adult Self-Report Scale Symptom Checklist, UPPS Impulsive Behavior Scale) |
| Measure | Description | Time Frame |
|---|---|---|
| Percentages for types I and III of the copy of the figure of Rey | 90 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Average scores for all cognitive and psychiatric tests | 90 minutes | |
| Measure of relationships between average scores for all cognitive and psychiatric tests and socio-demographic and clinical data | 90 minutes |
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Inclusion Criteria:
For the patients :
For the volunteers :
Exclusion Criteria:
For the patients :
Man
Age under 15 years and 3 months old
Current Renutrition by nasogastric tube
Personal history of:
Opposition of the patient and / or his legal representatives if minor
Subject under legal guardianship
Current participation or in the past to pharmacological research protocol (time since the end of their participation in the protocol less than one year)
French language not mastered
For the volunteers :
Man
Age under 15 years and 3 months old
Current Renutrition by nasogastric tube
Personal history of:
Opposition of the volunteer and / or his legal representatives if minor
Subject under legal guardianship
Current participation or in the past to pharmacological research protocol (time since the end of their participation in the protocol less than one year)
French language not mastered
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| Name | Affiliation | Role |
|---|---|---|
| Jennyfer CHOLET | Service d'Addictologie, CHU de Nantes, 44093 Nantes cedex 01, FRANCE | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nantes, Service d'Addictologie | Nantes | France |
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| ID | Term |
|---|---|
| D000856 | Anorexia Nervosa |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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