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| Name | Class |
|---|---|
| Oy Foodfiles Ltd | OTHER |
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While observational studies often find that diets rich in fish reduce the risk of disease, and that diets including a high intake of red meat are associated with increased risk of cardiovascular disease and cancer, the difference in health effects between red meat and fish are rarely researched in intervention studies.
The investigators hypothesise that the post-prandial plasma response of lipids and markers of cardiovascular disease risk will be more favourable after intake of herring compared to beef.
In addition, while pickling herring in a brine/sugar solution is a common form of preparation, little is known if there is a difference in potential health effects based on the preparation of herring. The investigators will compare baked and pickled herring to understand if preparation is potentially an important factor to be considered when looking at intake of fish and health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Baked beef | Active Comparator | A meal based on baked beef |
|
| Baked herring | Experimental | A meal based on baked herring |
|
| Pickled herring | Experimental | A meal based on pickled herring |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Baked beef | Other | A meal based on baked beef |
| |
| Baked herring |
| Measure | Description | Time Frame |
|---|---|---|
| Omega-3 fatty acids | Area under the curve between 0 and 7 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Plasms insulin | Area under the curve between 0 and 7 hours | |
| Plasma triglycerides | Area under the curve between 0 and 7 hours | |
| Plasma lipoprotein-cholesterol |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26400963 | Derived | Ross AB, Svelander C, Undeland I, Pinto R, Sandberg AS. Herring and Beef Meals Lead to Differences in Plasma 2-Aminoadipic Acid, beta-Alanine, 4-Hydroxyproline, Cetoleic Acid, and Docosahexaenoic Acid Concentrations in Overweight Men. J Nutr. 2015 Nov;145(11):2456-63. doi: 10.3945/jn.115.214262. Epub 2015 Sep 23. |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| Other |
A meal based on baked herring |
|
| Pickled herring | Other | A meal based on pickled herring |
|
| Area under the curve between 0 and 7 hours |
| Plasma vitamin D | Area under the curve between 0 and 7 hours |
| Plasma metabolomic profile | Area under the curve between 0 and 7 hours |
| Urinary metabolomics | Area under the curve between 0 and 7 hours |