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The main aims of the present project include 1) to study the longitudinal effects of whole-body vibratory exercise on bone metabolism in adolescents with and without DS and 2) to evaluate whether a low frequency vibratory training program consisting of 3 sessions per week for 9 months (each vibratory session last approximately 10 minutes and includes 5-6 bouts of 1 min with 1 min rest between bouts) can improve bone development in these populations. Finally, and additional aim of the project is 3) to determine how long these effects may last after the end of the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DS-WBV | Experimental | Exercise with Whole-body vibration (WBV) platform (Power Plate®). The participants will perform squat on a vibratory platform (3 times per week; 10 repetitions 30 to 60 seconds; Frequency: 25-30 Hz; Amplitude: 2 mm). |
|
| DS-NONWBV | No Intervention | This group will continue with their day-to-day lifestyle during the course of the project. | |
| NONDS-WBV | Experimental | Exercise with Whole-body vibration (WBV) platform (Power Plate®). The participants will perform squat on a vibratory platform (3 times per week; 10 repetitions 30 to 60 seconds; Frequency: 25-30 Hz; Amplitude: 2 mm). |
|
| NONDS-NONWBV | No Intervention | This group will continue with their day-to-day lifestyle during the course of the project. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whole-body vibration training (Power Plate®) on bone mass and bone metabolism in adolescents with and without Down syndrome. | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes from baseline in body composition assessed with dual energy X-ray at different time points, 6 months and 15 months. | Changes from baseline in body composition at 6 months and changes from baseline in body composition at 15 months |
| Measure | Description | Time Frame |
|---|---|---|
| Changes from baseline in bone structure evaluated with peripheral quantitative computed tomography at different time points, 6 months and 15 months. | Changes from baseline in bone structure at 6 months and changes from baseline in bone structure at 15 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| José A. Casajús, MD, PhD | GENUD Research Group | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| GENUD Research Group | Zaragoza | Zaragoza | 50009 | Spain |
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| ID | Term |
|---|---|
| D004314 | Down Syndrome |
| ID | Term |
|---|---|
| D008607 | Intellectual Disability |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D000015 | Abnormalities, Multiple |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D025063 | Chromosome Disorders |
| D030342 | Genetic Diseases, Inborn |
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