High cardiovascular risk patients will undergo H.E.L.P. apheresis.

High cardiovascular risk patients will undergo H.E.L.P. apheresis procedure every 3 weeks for 1 year.

We will evaluate the efficacy of apheretic technique through the reduction of Lp(a) in the plasma sample expressed by mg/dL.

We will evaluate the efficacy of apheretic technique through the improvement of inflammatory adypocytokines in the plasma sample.

We will evaluate the efficacy of apheretic technique through the reduction of total cholesterol, LDL and HDL cholesterol, and triglycerides in the plasma sample expressed by mg/dL.