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Identify the best combination of predictive variables that influence ionizing radiation dose and improved image quality through analysis and quantification of PET-CT images in simulators and patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Retrospective development cohort | A total of 85 18F-FDG-PET adult studies were gathered over a 3-month period and retrospectively evaluated. |
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| Prospective validation cohort | To verify the application of methodology in clinical routine, we conducted a second phase of the study prospectively in 250 subjects (phase 2) using inclusion and exclusion criteria of the retrospective study (phase 1). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Image quantify | Other | Will be observed all patients who perform PET / CT examinations, independent of clinical indication, in nuclear medicine at Hospital Sao Rafael. Those who show interest in participating in the study, will be provided free and informed consent form (ICF) for your appreciation. This evaluation will serve for analysis and quantification of PET-CT images. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of body weight with the variation coefficient (image noise). | The image noise will be measured by VOI (Volume Of Interest) in the images. The units of measure will be kilograms (kg) for body weight, and percentage for the variation coefficient. | 360 seconds |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of dose-regimen with the variation coefficient (image noise). | The dose-regimen will be calculated based on radiation dose and body surface. The image noise will be measured by VOI (Volume Of Interest) in the images. The units of measure will be MegaBecquerel per kilogram (MBq/kg) for dose-regimen, and percentage for the variation coefficient. | 360 seconds |
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Inclusion Criteria:
Exclusion Criteria:
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Will be observed all patients who perform PET / CT examinations, independent of clinical indication, in nuclear medicine at Hospital Sao Rafael. Those who show interest in participating in the study, will be provided free and informed consent form (ICF) for your appreciation. This evaluation will serve for analysis and quantification of PET-CT images.
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| Name | Affiliation | Role |
|---|---|---|
| Milena BP Soares, PhD | Hospital São Rafael | Principal Investigator |
| Vinicius O Menezes, BSc | Hospital São Rafael | Study Chair |
| Marcos AD Machado, BSc | Hospital São Rafael | Study Chair |
| Cleiton C Queiroz, BSc | Hospital São Rafael | Study Chair |
| Mauro Namias, MSc | Fundacion Centro Diagnostico Nuclear | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Sao Rafael | Salvador | Estado de Bahia | Brazil |
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| Correlation of acquisition protocol time with the variation coefficient (image noise). | Images will be acquired every 30 seconds until a maximum of 360 seconds. The image noise will be measured by VOI (Volume Of Interest) in the images. The units of measure will be seconds for the acquisition time, and percentage for the variation coefficient. | 360 seconds |
| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| D006689 | Hodgkin Disease |
| D008228 | Lymphoma, Non-Hodgkin |
| D003110 | Colonic Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D008223 | Lymphoma |
| D009370 | Neoplasms by Histologic Type |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
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