The aim of this randomized, double-blind, split-mouth clinical trial is to evaluate and compare the desensitizing efficacies of the resin-modified glass ionomer cement ClinproTM XT (3M ESPE, Minnesota, USA) and the conventional glass ionomer cement Vidrion R (SS White, Gloucester, UK) at 2-year follow-up.

Subjects will require to have at least two teeth in different hemiarchs with dentin hypersensitivity. Teeth will be randomized into 2 groups, receiving either Clinpro XT or the conventional glass ionomer cement Vidrion R. Prior to the desensitizing treatment (baseline), painful symptoms will be assessed by tactile and air blast tests using the Visual Analogue Scale (VAS). Treatment evaluations will be conducted up to 2-year post-treatment.

Inclusion Criteria:

• Male and female subjects between 18 and 70 years old
• At least 2 teeth with dentin hypersensitivity in two different hemiarchs
• Dental elements with hypersensitivity without any pulp alteration
• People who are not taking any medication and women who are not pregnant
• Patients without eating disorders or very acidic diets.

Exclusion Criteria:

• Teeth with hypersensitivity that presented extensive or unsatisfactory restorations, fractures, periodontal alterations, caries lesions, orthodontic brackets, endodontic treatments, pulp alterations.
• Subjects who received any desensitizing therapy during the last 3 months
• Subjects being under analgesics/anti-inflammatory drugs at the time of the study
• Teeth with hypersensitivity and non-carious cervical lesions

After completing the study, the 20 volunteers continued to be served sporadically at the regular dentistry service of the Faculty of Dentistry of Pelotas, Federal University of Pelotas (UFPel).